Abstract
The evolution of nevi is a complex process involving several constitutional and environmental factors. Although histopathology is the gold standard for the diagnosis and classification of melanocytic nevi, the widespread use of in vivo diagnostic technologies such as dermoscopy and more recently of reflectance confocal microscopy, has enriched profoundly our knowledge regarding the morphological variability of nevi in different stages of their evolution. In addition, significant progress has been made in our understanding of genetic alterations and molecular pathways involved in the formation of melanocytic tumors. All this newly acquired knowledge increasingly questions whether morphologically different nevi are also histiogenetically different. In this article, we intend to extract some of the salient points from published clinical and molecular studies on melanocytic tumors and attempt to assimilate them into an integrative concept of nevogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 16-24 |
| Number of pages | 9 |
| Journal | Journal of Dermatology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
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Keywords
- dermoscopy
- genetic
- nevi
- nevogenesis
ASJC Scopus subject areas
- Dermatology
Cite this
What dermoscopy tells us about nevogenesis. / Zalaudek, Iris; Catricalã, Caterina; Moscarella, Elvira; Argenziano, Giuseppe.
In: Journal of Dermatology, Vol. 38, No. 1, 01.2011, p. 16-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - What dermoscopy tells us about nevogenesis
AU - Zalaudek, Iris
AU - Catricalã, Caterina
AU - Moscarella, Elvira
AU - Argenziano, Giuseppe
PY - 2011/1
Y1 - 2011/1
N2 - The evolution of nevi is a complex process involving several constitutional and environmental factors. Although histopathology is the gold standard for the diagnosis and classification of melanocytic nevi, the widespread use of in vivo diagnostic technologies such as dermoscopy and more recently of reflectance confocal microscopy, has enriched profoundly our knowledge regarding the morphological variability of nevi in different stages of their evolution. In addition, significant progress has been made in our understanding of genetic alterations and molecular pathways involved in the formation of melanocytic tumors. All this newly acquired knowledge increasingly questions whether morphologically different nevi are also histiogenetically different. In this article, we intend to extract some of the salient points from published clinical and molecular studies on melanocytic tumors and attempt to assimilate them into an integrative concept of nevogenesis.
AB - The evolution of nevi is a complex process involving several constitutional and environmental factors. Although histopathology is the gold standard for the diagnosis and classification of melanocytic nevi, the widespread use of in vivo diagnostic technologies such as dermoscopy and more recently of reflectance confocal microscopy, has enriched profoundly our knowledge regarding the morphological variability of nevi in different stages of their evolution. In addition, significant progress has been made in our understanding of genetic alterations and molecular pathways involved in the formation of melanocytic tumors. All this newly acquired knowledge increasingly questions whether morphologically different nevi are also histiogenetically different. In this article, we intend to extract some of the salient points from published clinical and molecular studies on melanocytic tumors and attempt to assimilate them into an integrative concept of nevogenesis.
KW - dermoscopy
KW - genetic
KW - nevi
KW - nevogenesis
UR - http://www.scopus.com/inward/record.url?scp=78650685913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650685913&partnerID=8YFLogxK
U2 - 10.1111/j.1346-8138.2010.01141.x
DO - 10.1111/j.1346-8138.2010.01141.x
M3 - Article
C2 - 21175751
AN - SCOPUS:78650685913
VL - 38
SP - 16
EP - 24
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 1
ER -