What Do We Know About Clodronate Now? A Medical and Veterinary Perspective

Richard Markell, Gianantonio Saviola, Elizabeth Ann Barker, James Daniel Conway, Chris Dujardin

Research output: Contribution to journalReview articlepeer-review


There has recently been some controversy over the use of bisphosphonates in horses and some confusion regarding the different classes of bisphosphonates and the differences between the mechanism of actions and effects of each class. This review article explores the different bisphosphonate classes and their different effects and mechanisms of action based on research from both the human and equine veterinary fields. This collaborative review between veterinary surgeons and medical doctors describes the latest use of bisphosphonates in humans and horses, including safety aspects, and allows comparisons to be drawn between the two fields. Potential future uses of bisphosphonates are also discussed.

Original languageEnglish
Article number102874
JournalJournal of Equine Veterinary Science
Publication statusPublished - May 2020


  • Bisphosphonate
  • Clodronate
  • Horse
  • Lameness
  • Navicular syndrome
  • Osteoarthritis

ASJC Scopus subject areas

  • Equine


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