What does irritable bowel syndrome share with non-alcoholic fatty liver disease?

Antonella Scalera, Matteo Nicola Dario Di Minno, Giovanni Tarantino

Research output: Contribution to journalArticlepeer-review

Abstract

Non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) are two very common diseases in the general population. To date, there are no studies that highlight a direct link between NAFLD and IBS, but some recent reports have found an interesting correlation between obesity and IBS. A systematic PubMed database search was conducted highlighting that common mechanisms are involved in many of the local and systemic manifestations of NAFLD, leading to an increased cardiovascular risk, and IBS, leading to microbial dysbiosis, impaired intestinal barrier and altered intestinal motility. It is not known when considering local and systemic inflammation/immune system activation, which one has greater importance in NAFLD and IBS pathogenesis. Also, the nervous system is implicated. In fact, inflammation participates in the development of mood disorders, such as anxiety and depression, characteristics of obesity and consequently of NAFLD and, on the other hand, in intestinal hypersensitivity and dysmotility.

Original languageEnglish
Pages (from-to)5402-5420
Number of pages19
JournalWorld Journal of Gastroenterology
Volume19
Issue number33
DOIs
Publication statusPublished - 2013

Keywords

  • Cytokines
  • Irritable bowel syndrome
  • Low grade chronic inflammation
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Gastroenterology

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