What does the corpus callosum tell us about brain changes in the elderly?

Research output: Contribution to journalArticlepeer-review


Evaluation of: Ryberg C, Rostrup E, Paulson OB et al. On behalf of the LADIS study group. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3 year follow-up of the LADIS study cohort. J. Neurol. Sci. 307(1-2), 100-105 (2011). The corpus callosum is the largest hemispheric interconnection bundle in the human brain. Its anterior-posterior fiber caliber gradient can help in understanding the pathophysiological mechanisms underlying white matter changes both in old age and dementia. Here, the Leukoaraiosis and Disability (LADIS) study, a longitudinal cohort study, which shows an association between corpus callosum atrophy and cognitive and motor decline in the elderly, provides the possibility to consider the use of multimodal macro-microstructural imaging of corpus callosum as a marker of structural brain changes of physiological and pathological aging.

Original languageEnglish
Pages (from-to)1557-1560
Number of pages4
JournalExpert Review of Neurotherapeutics
Issue number11
Publication statusPublished - Nov 2011


  • age-related white matter changes
  • corpus callosum
  • demyelination process
  • diffusion tensor imaging
  • elderly
  • region of interest
  • Wallerian degeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)


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