What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons

Claudio Babiloni, Katarzyna Blinowska, Laura Bonanni, Andrej Cichocki, Willem De Haan, Claudio Del Percio, Bruno Dubois, Javier Escudero, Alberto Fernández, Giovanni Frisoni, Bahar Guntekin, Mihaly Hajos, Harald Hampel, Emmanuel Ifeachor, Kerry Kilborn, Sanjeev Kumar, Kristinn Johnsen, Magnus Johannsson, Jaeseung Jeong, Fiona LeBeauRoberta Lizio, Fernando Lopes da Silva, Fernando Maestú, William J McGeown, Ian McKeith, Davide Vito Moretti, Flavio Nobili, John Olichney, Marco Onofrj, Jorge J Palop, Michael Rowan, Fabrizio Stocchi, Zbigniew M Struzik, Heikki Tanila, Stefan Teipel, John Paul Taylor, Marco Weiergräber, Gorsev Yener, Tracy Young-Pearse, Wilhelmus H Drinkenburg, Fiona Randall

Research output: Contribution to journalArticle

Abstract

Electrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic (EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in patients with Alzheimer's disease (AD), despite a surge in recent validated evidence. This position paper of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational electrophysiological techniques applied to both experimental animal models of AD and patients, to probe the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as well as brain network dynamics, synchronization, and functional connectivity, reflecting thalamocortical and corticocortical residual capacity. Converging evidence shows relationships between abnormalities in EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting evidence for the application of electrophysiology in AD clinical research as well as drug discovery pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main multicentric projects planned in AD patients, to produce conclusive findings challenging the present regulatory requirements and guidelines for AD studies.
Original languageEnglish
Number of pages16
JournalNeurobiology of Aging
DOIs
Publication statusE-pub ahead of print - 2019

Keywords

  • Alzheimer's disease (AD)
  • Electroencephalography and magnetoencephalography (EEG and MEG)
  • Event-related potentials and magnetic fields
  • Preclinical and clinical research
  • Resting-state condition
  • The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)

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    Babiloni, C., Blinowska, K., Bonanni, L., Cichocki, A., De Haan, W., Del Percio, C., Dubois, B., Escudero, J., Fernández, A., Frisoni, G., Guntekin, B., Hajos, M., Hampel, H., Ifeachor, E., Kilborn, K., Kumar, S., Johnsen, K., Johannsson, M., Jeong, J., ... Randall, F. (2019). What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2019.09.008