What is New in Melanoma Genetics and Treatment?

Simone Ribero, Caterina Longo, Dan Glass, Paul Nathan, Veronique Bataille

Research output: Contribution to journalReview articlepeer-review

Abstract

New therapies for advanced melanoma have led to major advances, which, for the first time, showed improved survival for patients with this very challenging neoplasm. These new treatments are based on gene-targeted therapies or stimulation of immune responses. However, these treatments are not without challenges in terms of resistance and toxicity. Physicians should be aware of these side effects as prompt treatment may save lives. Melanoma genetics is also unravelling new genetic risk factors involving telomere genes as well as new gene pathways at the somatic level which may soon become therapeutic targets. It is also shedding new light onto the pathology of this tumour with links to neural diseases and longevity.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalDermatology
Volume232
Issue number3
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Genetics
  • Melanoma
  • Therapy

ASJC Scopus subject areas

  • Dermatology

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