What is the contribution of differences in three measures of tumor necrosis factor-alpha activity to insulin resistance in healthy volunteers?

I. Zavaroni, F. Numeroso, P. Dongiovanni, D. Ardigò, L. Valenti, A. L. Fracanzani, S. Valtuen̂a, R. Delsignore, S. Fargion, G. M. Reaven

Research output: Contribution to journalArticle

Abstract

To address the potential role that tumor necrosis factor-alpha (TNF-α) might play in modulation of insulin resistance in healthy, nondiabetic individuals, we compared plasma TNF-α and soluble TNF-α receptor 2 (sTNF-R2) concentrations, as well as TNF-α polymorphisms, in 94 healthy individuals, stratified into insulin-resistant (IR) and insulin-sensitive (IS) groups based on their plasma insulin concentrations 120 minutes after oral glucose on 2 occasions (1993 and 2000). The IR group (n = 50; 29 men and 21 women) was in the upper quartile and the IS group (n = 44; 24 men and 20 women) in the lowest quartile of the distribution of post-glucose challenge insulin concentrations in a large unselected population (>50 v

Original languageEnglish
Pages (from-to)1593-1596
Number of pages4
JournalMetabolism
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 2003

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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