What is the current evidence on vertebral body osteonecrosis? A systematic review of the literature

Matteo Formica, Andrea Zanirato, Luca Cavagnaro, Marco Basso, Stefano Divano, Carlo Formica, Lamberto Felli

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Osteonecrosis (ON) is a clinical entity characterized by a pattern of cell death and complex process of bone resorption and formation. Studies related to ON have largely focused on certain anatomical sites; however, the evidence on vertebral body ON (VBON) is largely inconsistent and fragmented. The aim of this study was to clarify the pathophysiology, risk factors, imaging findings, and available treatment modalities for VBON. A systematic review of the relevant articles published in English was performed using PubMed, Embase, Medline, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL databases. A total of 81 articles were included in this study. Three main topics about VBON were identified: (1) pathophysiology and risk factors, (2) diagnosis, and (3) treatment. Forty-five studies were based on the pathophysiology, 52 on diagnosis, and 38 on the treatment options for VBON. The literature on VBON was limited and mainly focused on post-traumatic cases with a considerable overlap with nonunion and pseudoarthrosis.

Original languageEnglish
Pages (from-to)586-599
Number of pages14
JournalAsian Spine Journal
Volume12
Issue number23
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Osteonecrosis
Pseudarthrosis
Bone Resorption
PubMed
Osteogenesis
Cell Death
Databases

Keywords

  • Bone necrosis
  • Diagnosis
  • Outcomes
  • Spine
  • Treatment
  • Vertebral body

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

What is the current evidence on vertebral body osteonecrosis? A systematic review of the literature. / Formica, Matteo; Zanirato, Andrea; Cavagnaro, Luca; Basso, Marco; Divano, Stefano; Formica, Carlo; Felli, Lamberto.

In: Asian Spine Journal, Vol. 12, No. 23, 01.06.2018, p. 586-599.

Research output: Contribution to journalReview article

Formica, M, Zanirato, A, Cavagnaro, L, Basso, M, Divano, S, Formica, C & Felli, L 2018, 'What is the current evidence on vertebral body osteonecrosis? A systematic review of the literature', Asian Spine Journal, vol. 12, no. 23, pp. 586-599. https://doi.org/10.4184/asj.2018.12.3.586
Formica, Matteo ; Zanirato, Andrea ; Cavagnaro, Luca ; Basso, Marco ; Divano, Stefano ; Formica, Carlo ; Felli, Lamberto. / What is the current evidence on vertebral body osteonecrosis? A systematic review of the literature. In: Asian Spine Journal. 2018 ; Vol. 12, No. 23. pp. 586-599.
@article{491b9fb7dad848e2b1acdcab7954119b,
title = "What is the current evidence on vertebral body osteonecrosis?: A systematic review of the literature",
abstract = "Osteonecrosis (ON) is a clinical entity characterized by a pattern of cell death and complex process of bone resorption and formation. Studies related to ON have largely focused on certain anatomical sites; however, the evidence on vertebral body ON (VBON) is largely inconsistent and fragmented. The aim of this study was to clarify the pathophysiology, risk factors, imaging findings, and available treatment modalities for VBON. A systematic review of the relevant articles published in English was performed using PubMed, Embase, Medline, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL databases. A total of 81 articles were included in this study. Three main topics about VBON were identified: (1) pathophysiology and risk factors, (2) diagnosis, and (3) treatment. Forty-five studies were based on the pathophysiology, 52 on diagnosis, and 38 on the treatment options for VBON. The literature on VBON was limited and mainly focused on post-traumatic cases with a considerable overlap with nonunion and pseudoarthrosis.",
keywords = "Bone necrosis, Diagnosis, Outcomes, Spine, Treatment, Vertebral body",
author = "Matteo Formica and Andrea Zanirato and Luca Cavagnaro and Marco Basso and Stefano Divano and Carlo Formica and Lamberto Felli",
year = "2018",
month = "6",
day = "1",
doi = "10.4184/asj.2018.12.3.586",
language = "English",
volume = "12",
pages = "586--599",
journal = "Asian Spine Journal",
issn = "1976-1902",
publisher = "Korean Society of Spine Surgery",
number = "23",

}

TY - JOUR

T1 - What is the current evidence on vertebral body osteonecrosis?

T2 - A systematic review of the literature

AU - Formica, Matteo

AU - Zanirato, Andrea

AU - Cavagnaro, Luca

AU - Basso, Marco

AU - Divano, Stefano

AU - Formica, Carlo

AU - Felli, Lamberto

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Osteonecrosis (ON) is a clinical entity characterized by a pattern of cell death and complex process of bone resorption and formation. Studies related to ON have largely focused on certain anatomical sites; however, the evidence on vertebral body ON (VBON) is largely inconsistent and fragmented. The aim of this study was to clarify the pathophysiology, risk factors, imaging findings, and available treatment modalities for VBON. A systematic review of the relevant articles published in English was performed using PubMed, Embase, Medline, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL databases. A total of 81 articles were included in this study. Three main topics about VBON were identified: (1) pathophysiology and risk factors, (2) diagnosis, and (3) treatment. Forty-five studies were based on the pathophysiology, 52 on diagnosis, and 38 on the treatment options for VBON. The literature on VBON was limited and mainly focused on post-traumatic cases with a considerable overlap with nonunion and pseudoarthrosis.

AB - Osteonecrosis (ON) is a clinical entity characterized by a pattern of cell death and complex process of bone resorption and formation. Studies related to ON have largely focused on certain anatomical sites; however, the evidence on vertebral body ON (VBON) is largely inconsistent and fragmented. The aim of this study was to clarify the pathophysiology, risk factors, imaging findings, and available treatment modalities for VBON. A systematic review of the relevant articles published in English was performed using PubMed, Embase, Medline, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL databases. A total of 81 articles were included in this study. Three main topics about VBON were identified: (1) pathophysiology and risk factors, (2) diagnosis, and (3) treatment. Forty-five studies were based on the pathophysiology, 52 on diagnosis, and 38 on the treatment options for VBON. The literature on VBON was limited and mainly focused on post-traumatic cases with a considerable overlap with nonunion and pseudoarthrosis.

KW - Bone necrosis

KW - Diagnosis

KW - Outcomes

KW - Spine

KW - Treatment

KW - Vertebral body

UR - http://www.scopus.com/inward/record.url?scp=85049053899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049053899&partnerID=8YFLogxK

U2 - 10.4184/asj.2018.12.3.586

DO - 10.4184/asj.2018.12.3.586

M3 - Review article

AN - SCOPUS:85049053899

VL - 12

SP - 586

EP - 599

JO - Asian Spine Journal

JF - Asian Spine Journal

SN - 1976-1902

IS - 23

ER -