Abstract
Pregnancy complications are a frequent and unsolved condition in patients with antiphospholipid syndrome (APS). Women with antiphospholipid antibodies (aPL) are at high risk of recurrent early pregnancy loss, as well as late obstetrical complications associated with impaired placental function, such as preeclampsia, intrauterine growth restriction, and prematurity. Thrombotic events at the maternal–fetal interface were originally thought to underlie aPL-associated pregnancy complications, due to the partial beneficial effects of heparin. However, more recent clinical and experimental observations suggest, instead, that non-thrombotic events may play a primary role in the pathophysiology of pregnancy complications in APS patients, including complement activation, inflammation, and disruption of normal trophoblast function. This chapter will review the known pathogenic mechanisms of pregnancy complications in APS and provide a helpful instrument to all the workers in the field from both a clinical and basic view.
| Original language | English |
|---|---|
| Title of host publication | Antiphospholipid Syndrome: Insights and Highlights from the 13Th International Congress on Antiphospholipid Antibodies |
| Publisher | Springer US |
| Pages | 79-101 |
| Number of pages | 23 |
| ISBN (Print) | 9781461431947, 9781461431930 |
| DOIs | |
| Publication status | Published - Jan 1 2012 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
What is the mechanism(S) of antiphospholipid antibody-mediated pregnancy morbidity? / Abrahams, Vikki M.; Borghi, Maria O.; Meroni, Pier Luigi; Rand, Jacob H.; Raschi, ElenA; Salmon, Jane E.; Tedesco, Francesco; Tincani, AngelA.
Antiphospholipid Syndrome: Insights and Highlights from the 13Th International Congress on Antiphospholipid Antibodies. Springer US, 2012. p. 79-101.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - What is the mechanism(S) of antiphospholipid antibody-mediated pregnancy morbidity?
AU - Abrahams, Vikki M.
AU - Borghi, Maria O.
AU - Meroni, Pier Luigi
AU - Rand, Jacob H.
AU - Raschi, ElenA
AU - Salmon, Jane E.
AU - Tedesco, Francesco
AU - Tincani, AngelA
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Pregnancy complications are a frequent and unsolved condition in patients with antiphospholipid syndrome (APS). Women with antiphospholipid antibodies (aPL) are at high risk of recurrent early pregnancy loss, as well as late obstetrical complications associated with impaired placental function, such as preeclampsia, intrauterine growth restriction, and prematurity. Thrombotic events at the maternal–fetal interface were originally thought to underlie aPL-associated pregnancy complications, due to the partial beneficial effects of heparin. However, more recent clinical and experimental observations suggest, instead, that non-thrombotic events may play a primary role in the pathophysiology of pregnancy complications in APS patients, including complement activation, inflammation, and disruption of normal trophoblast function. This chapter will review the known pathogenic mechanisms of pregnancy complications in APS and provide a helpful instrument to all the workers in the field from both a clinical and basic view.
AB - Pregnancy complications are a frequent and unsolved condition in patients with antiphospholipid syndrome (APS). Women with antiphospholipid antibodies (aPL) are at high risk of recurrent early pregnancy loss, as well as late obstetrical complications associated with impaired placental function, such as preeclampsia, intrauterine growth restriction, and prematurity. Thrombotic events at the maternal–fetal interface were originally thought to underlie aPL-associated pregnancy complications, due to the partial beneficial effects of heparin. However, more recent clinical and experimental observations suggest, instead, that non-thrombotic events may play a primary role in the pathophysiology of pregnancy complications in APS patients, including complement activation, inflammation, and disruption of normal trophoblast function. This chapter will review the known pathogenic mechanisms of pregnancy complications in APS and provide a helpful instrument to all the workers in the field from both a clinical and basic view.
UR - http://www.scopus.com/inward/record.url?scp=84875955108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875955108&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-3194-7_5
DO - 10.1007/978-1-4614-3194-7_5
M3 - Chapter
AN - SCOPUS:84875955108
SN - 9781461431947
SN - 9781461431930
SP - 79
EP - 101
BT - Antiphospholipid Syndrome: Insights and Highlights from the 13Th International Congress on Antiphospholipid Antibodies
PB - Springer US
ER -