What is the source of elevated serum levels of CA 125 in patients with endometriosis?

Luigi Fedele, Luisa Arcaini, Andrea Baglioni, Stefano Bianchi, Silvie Menard

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The presence of CA 125 was investigated in endometriotic tissue and endometrial mucosa using two different immunohistochemical methods, indirect immunofluorescence and the avidin-biotin immunoperoxidase technique. Neither of the methods revealed the antigen in the 12 endometriotic fragments studied. The endometrial mucosa both of patients with endometriosis and of the control subjects was positive with indirect immunoperoxidase staining in all cases, whereas with indirect immunofluorescence it was positive in 75 and 67%, respectively. Thus the mechanism(s) responsible for distribution of the antigen in different tissues and its reported high serum levels in advanced endometriosis is still unclear.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume33
Issue number3
DOIs
Publication statusPublished - 1989

Fingerprint

Endometriosis
Indirect Fluorescent Antibody Technique
Mucous Membrane
Antigens
Avidin
Biotin
Serum
Immunoenzyme Techniques
Staining and Labeling

Keywords

  • CA 125
  • Endometriosis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

What is the source of elevated serum levels of CA 125 in patients with endometriosis? / Fedele, Luigi; Arcaini, Luisa; Baglioni, Andrea; Bianchi, Stefano; Menard, Silvie.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 33, No. 3, 1989, p. 247-252.

Research output: Contribution to journalArticle

Fedele, Luigi ; Arcaini, Luisa ; Baglioni, Andrea ; Bianchi, Stefano ; Menard, Silvie. / What is the source of elevated serum levels of CA 125 in patients with endometriosis?. In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 1989 ; Vol. 33, No. 3. pp. 247-252.
@article{7ab0b15cc78c4960a51778d2915d3f51,
title = "What is the source of elevated serum levels of CA 125 in patients with endometriosis?",
abstract = "The presence of CA 125 was investigated in endometriotic tissue and endometrial mucosa using two different immunohistochemical methods, indirect immunofluorescence and the avidin-biotin immunoperoxidase technique. Neither of the methods revealed the antigen in the 12 endometriotic fragments studied. The endometrial mucosa both of patients with endometriosis and of the control subjects was positive with indirect immunoperoxidase staining in all cases, whereas with indirect immunofluorescence it was positive in 75 and 67{\%}, respectively. Thus the mechanism(s) responsible for distribution of the antigen in different tissues and its reported high serum levels in advanced endometriosis is still unclear.",
keywords = "CA 125, Endometriosis",
author = "Luigi Fedele and Luisa Arcaini and Andrea Baglioni and Stefano Bianchi and Silvie Menard",
year = "1989",
doi = "10.1016/0028-2243(89)90137-8",
language = "English",
volume = "33",
pages = "247--252",
journal = "European Journal of Obstetrics, Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - What is the source of elevated serum levels of CA 125 in patients with endometriosis?

AU - Fedele, Luigi

AU - Arcaini, Luisa

AU - Baglioni, Andrea

AU - Bianchi, Stefano

AU - Menard, Silvie

PY - 1989

Y1 - 1989

N2 - The presence of CA 125 was investigated in endometriotic tissue and endometrial mucosa using two different immunohistochemical methods, indirect immunofluorescence and the avidin-biotin immunoperoxidase technique. Neither of the methods revealed the antigen in the 12 endometriotic fragments studied. The endometrial mucosa both of patients with endometriosis and of the control subjects was positive with indirect immunoperoxidase staining in all cases, whereas with indirect immunofluorescence it was positive in 75 and 67%, respectively. Thus the mechanism(s) responsible for distribution of the antigen in different tissues and its reported high serum levels in advanced endometriosis is still unclear.

AB - The presence of CA 125 was investigated in endometriotic tissue and endometrial mucosa using two different immunohistochemical methods, indirect immunofluorescence and the avidin-biotin immunoperoxidase technique. Neither of the methods revealed the antigen in the 12 endometriotic fragments studied. The endometrial mucosa both of patients with endometriosis and of the control subjects was positive with indirect immunoperoxidase staining in all cases, whereas with indirect immunofluorescence it was positive in 75 and 67%, respectively. Thus the mechanism(s) responsible for distribution of the antigen in different tissues and its reported high serum levels in advanced endometriosis is still unclear.

KW - CA 125

KW - Endometriosis

UR - http://www.scopus.com/inward/record.url?scp=0024833503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024833503&partnerID=8YFLogxK

U2 - 10.1016/0028-2243(89)90137-8

DO - 10.1016/0028-2243(89)90137-8

M3 - Article

VL - 33

SP - 247

EP - 252

JO - European Journal of Obstetrics, Gynecology and Reproductive Biology

JF - European Journal of Obstetrics, Gynecology and Reproductive Biology

SN - 0028-2243

IS - 3

ER -