What neurophysiological recordings tell us about cognitive and behavioral functions of the human subthalamic nucleus

Sara Marceglia, Manuela Fumagalli, Alberto Priori

Research output: Contribution to journalArticlepeer-review

Abstract

The behavioral implications of deep brain stimulation (DBS) observed in Parkinsons disease patients provided evidence for a possible nonexclusively motor role of the subthalamic nucleus (STN) in basal ganglia circuitry. Basal ganglia pathophysiology can be studied directly by the analysis of neural rhythms measured in local field potentials recorded through DBS electrodes. Recent studies demonstrated that specific oscillations in the STN are involved in cognitive and behavioral information processing: action representation is mediated through oscillations (13-35 Hz); cognitive information related to decision-making processes is mediated through the low-frequency oscillation (5-12 Hz); and limbic and emotional information is mediated through the α oscillation (8-12 Hz). These results revealed an important involvement of STN in decisional processes, cognitive functions, emotion control and conflict that could explain the post-DBS occurrence of behavioral disturbances.

Original languageEnglish
Pages (from-to)139-149
Number of pages11
JournalExpert Review of Neurotherapeutics
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • action understanding
  • deep brain stimulation
  • emotional processing
  • local field potentials
  • non-motor functions
  • Parkinsons disease
  • social decision-making

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)

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