TY - JOUR
T1 - What's growing on? the growing teratoma syndrome
AU - Denaro, Luca
AU - Pluchinotta, Francesca
AU - Faggin, Roberto
AU - Manara, Renzo
AU - Calderone, Milena
AU - Viscardi, Elisabetta
AU - Gardiman, Marina
AU - Rossetto, Marta
AU - Perilongo, Giorgio
AU - D'Avella, Domenico
PY - 2010/11
Y1 - 2010/11
N2 - Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.
AB - Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.
KW - Chemotherapy
KW - Growing teratoma syndrome
KW - Nongerminomatous germ-cell tumor
KW - Teratoma
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U2 - 10.1007/s00701-010-0807-2
DO - 10.1007/s00701-010-0807-2
M3 - Article
C2 - 20878531
AN - SCOPUS:78149364416
VL - 152
SP - 1943
EP - 1946
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
IS - 11
ER -