What's growing on? the growing teratoma syndrome

Luca Denaro; Francesca Pluchinotta; Roberto Faggin; Renzo Manara; Milena Calderone; Elisabetta Viscardi; Marina Gardiman; Marta Rossetto; Giorgio Perilongo; Domenico D'Avella

doi:10.1007/s00701-010-0807-2

What's growing on? the growing teratoma syndrome

Luca Denaro, Francesca Pluchinotta, Roberto Faggin, Renzo Manara, Milena Calderone, Elisabetta Viscardi, Marina Gardiman, Marta Rossetto, Giorgio Perilongo, Domenico D'Avella

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.

Original language	English
Pages (from-to)	1943-1946
Number of pages	4
Journal	Acta Neurochirurgica
Volume	152
Issue number	11
DOIs	https://doi.org/10.1007/s00701-010-0807-2
Publication status	Published - Nov 2010

Keywords

Chemotherapy
Growing teratoma syndrome
Nongerminomatous germ-cell tumor
Teratoma

ASJC Scopus subject areas

Clinical Neurology
Surgery

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10.1007/s00701-010-0807-2

Cite this

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title = "What's growing on? the growing teratoma syndrome",

abstract = "Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.",

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T1 - What's growing on? the growing teratoma syndrome

AU - Denaro, Luca

AU - Pluchinotta, Francesca

AU - Faggin, Roberto

AU - Manara, Renzo

AU - Calderone, Milena

AU - Viscardi, Elisabetta

AU - Gardiman, Marina

AU - Rossetto, Marta

AU - Perilongo, Giorgio

AU - D'Avella, Domenico

PY - 2010/11

Y1 - 2010/11

N2 - Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.

AB - Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.

KW - Chemotherapy

KW - Growing teratoma syndrome

KW - Nongerminomatous germ-cell tumor

KW - Teratoma

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What's growing on? the growing teratoma syndrome

Abstract

Keywords

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