What's growing on? the growing teratoma syndrome

Luca Denaro, Francesca Pluchinotta, Roberto Faggin, Renzo Manara, Milena Calderone, Elisabetta Viscardi, Marina Gardiman, Marta Rossetto, Giorgio Perilongo, Domenico D'Avella

Research output: Contribution to journalArticlepeer-review


Background: The growing teratoma syndrome (GTS) consists of a mature teratoma paradoxically enlarging during or after chemotherapy for malignant nongerminomatous germ cell tumors. Methods and results: We report two cases of GTS occurring in association with NSGCT of the pineal gland. Although an unusual event, clinicians and radiologists should be aware of its natural history. Conclusions: When normalized tumor markers after chemotherapy are associated with imaging features of a growing mass, the hypothesis of GTS must be taken in consideration. When early diagnosed, GTS can be managed surgically with good results.

Original languageEnglish
Pages (from-to)1943-1946
Number of pages4
JournalActa Neurochirurgica
Issue number11
Publication statusPublished - Nov 2010


  • Chemotherapy
  • Growing teratoma syndrome
  • Nongerminomatous germ-cell tumor
  • Teratoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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