What's new in musculoskeletal oncology

Costantino Errani, Andreas F Mavrogenis, Shinji Tsukamoto

Research output: Contribution to journalReview articlepeer-review


We reviewed the recent literature related to primary musculoskeletal tumors and metastatic bone tumors. With regard to primary bone tumors, computer navigation systems and three-dimensional-printed prostheses seem to be new treatment options, especially in challenging anatomical locations, such as the sacrum and pelvis. Regarding the treatment of giant cell tumor of bone, recent studies have suggested that denosumab administration is related to a higher local recurrence rate following curettage, but a lower local recurrence rate following en bloc resection. In addition, there was no difference in the local recurrence rate at five years after surgery between short-term and long-term denosumab therapy. With regard to soft tissue tumors, percutaneous cryoablation appears to be a new treatment option for extra-abdominal desmoid tumors, with encouraging results. Regarding soft tissue sarcomas, a negative surgical margin of < 1 mm is sufficient to control local recurrence. Pexidartinib seems to be a promising systemic therapy for the treatment of tenosynovial giant cell tumors for which surgery is not expected to improve the function of the affected limb. Finally, the life expectancy of patients is the most important factor in determining the optimal surgical procedure for patients with impending or pathological fractures of the long bone due to metastatic bone tumors. Elevated C-reactive protein level was found to be an independent poor prognostic factor at 1 year after surgery for long bone metastases.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBMC Musculoskelet. Disord.
Issue number1
Publication statusPublished - Aug 17 2021


  • Bone metastases
  • Bone sarcomas
  • Bone tumors
  • Metastatic bone tumor
  • Musculoskeletal tumors
  • New treatments
  • Soft tissue sarcomas
  • Soft tissue tumors
  • What’s new


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