All too often medical practice has been adversely affected by acrytical acceptance of indications based on attractive hypotheses rather than scientific evidence. The monotherapy-polytherapy controversy is a good example. From the initial enthusiasm for the never demonstrated advantages of combining different drugs at low dosages the pendulum swang almost to the demonization of polytherapy before returning recently to the ill-defined concept of rational polytherapy. In fact, therapeutic practice can only be based on evaluation of the individual characteristics of the patient and available scientific evidence: monotherapy and polytherapy are not incompatible strategies, but complementary approaches whose utilization is bound to improve with advances in knowledge.
|Translated title of the contribution||When are two drugs better than one?|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Clinical Neurology