Quando due farmaci sono meglio di uno?

Translated title of the contribution: When are two drugs better than one?

I. Bonomi, G. Yannuzzi, E. Perucca

Research output: Contribution to journalArticlepeer-review


All too often medical practice has been adversely affected by acrytical acceptance of indications based on attractive hypotheses rather than scientific evidence. The monotherapy-polytherapy controversy is a good example. From the initial enthusiasm for the never demonstrated advantages of combining different drugs at low dosages the pendulum swang almost to the demonization of polytherapy before returning recently to the ill-defined concept of rational polytherapy. In fact, therapeutic practice can only be based on evaluation of the individual characteristics of the patient and available scientific evidence: monotherapy and polytherapy are not incompatible strategies, but complementary approaches whose utilization is bound to improve with advances in knowledge.

Translated title of the contributionWhen are two drugs better than one?
Original languageItalian
Pages (from-to)333-335
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number106-107
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Clinical Neurology


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