When chocolate seeking becomes compulsion: Gene-environment interplay

Enrico Patrono, Matteo Di Segni, Loris Patella, Diego Andolina, Alessandro Valzania, Emanuele Claudio Latagliata, Armando Felsani, Assunta Pompili, Antonella Gasbarri, Stefano Puglisi-Allegra, Rossella Ventura

Research output: Contribution to journalArticle

Abstract

Background: Eating disorders appear to be caused by a complex interaction between environmental and genetic factors, and compulsive eating in response to adverse circumstances characterizes many eating disorders. Materials and Methods: We compared compulsion-like eating in the form of conditioned suppression of palatable food-seeking in adverse situations in stressed C57BL/6J and DBA/2J mice, two well-characterized inbred strains, to determine the influence of gene-environment interplay on this behavioral phenotype. Moreover, we tested the hypothesis that low accumbal D2 receptor (R) availability is a genetic risk factor of food compulsion-like behavior and that environmental conditions that induce compulsive eating alter D2R expression in the striatum. To this end, we measured D1R and D2R expression in the striatum and D1R, D2R and α1R levels in the medial prefrontal cortex, respectively, by western blot. Results Exposure to environmental conditions induces compulsion-like eating behavior, depending on genetic background. This behavioral pattern is linked to decreased availability of accumbal D2R. Moreover, exposure to certain environmental conditions upregulates D2R and downregulates α1R in the striatumand medial prefrontal cortex, respectively, of compulsive animals. These findings confirm the function of gene-environment interplay in themanifestation of compulsive eating and support the hypothesis that low accumbal D2R availability is a "constitutive" genetic risk factor for compulsion-like eating behavior. Finally, D2R upregulation and α1R downregulation in the striatum and medial prefrontal cortex, respectively, are potential neuroadaptive responses that parallel the shift from motivated to compulsive eating.

Original languageEnglish
Article numbere0120191
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 17 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'When chocolate seeking becomes compulsion: Gene-environment interplay'. Together they form a unique fingerprint.

  • Cite this

    Patrono, E., Segni, M. D., Patella, L., Andolina, D., Valzania, A., Latagliata, E. C., Felsani, A., Pompili, A., Gasbarri, A., Puglisi-Allegra, S., & Ventura, R. (2015). When chocolate seeking becomes compulsion: Gene-environment interplay. PLoS One, 10(3), [e0120191]. https://doi.org/10.1371/journal.pone.0120191