When Pulmonary Hypertension Complicates Heart Failure

Alberto Maria Marra, Nicola Benjamin, Antonio Cittadini, Eduardo Bossone, Ekkehard Grünig

Research output: Contribution to journalReview articlepeer-review


Pulmonary hypertension (PH) often complicates chronic left-sided heart failure, with a remarkable impact on quality of life, exercise capacity, and survival. PH in chronic left-sided heart failure (PH-LHD) is not only caused by backward transmission of pressures but also involves impairment of atrial function, inflammation, and vasoconstriction. Once the left atrium loses its reservoir capacity, usually pulmonary vascular resistances increase. Right atrial dilation commonly represents the first sign of PH-LHD, before right ventricle dilatation and systolic dysfunction develop, leading to right heart insufficiency, and ultimately, right heart failure.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalHeart Failure Clinics
Issue number1
Publication statusPublished - Jan 2020


  • Chronic heart failure
  • Heart failure with preserved ejection fraction
  • Pulmonary hypertension
  • Right ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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