When Pulmonary Hypertension Complicates Heart Failure

Alberto Maria Marra; Nicola Benjamin; Antonio Cittadini; Eduardo Bossone; Ekkehard Grünig

doi:10.1016/j.hfc.2019.08.004

When Pulmonary Hypertension Complicates Heart Failure

Alberto Maria Marra, Nicola Benjamin, Antonio Cittadini, Eduardo Bossone, Ekkehard Grünig

IRCCS SDN

Research output: Contribution to journal › Review article › peer-review

Abstract

Pulmonary hypertension (PH) often complicates chronic left-sided heart failure, with a remarkable impact on quality of life, exercise capacity, and survival. PH in chronic left-sided heart failure (PH-LHD) is not only caused by backward transmission of pressures but also involves impairment of atrial function, inflammation, and vasoconstriction. Once the left atrium loses its reservoir capacity, usually pulmonary vascular resistances increase. Right atrial dilation commonly represents the first sign of PH-LHD, before right ventricle dilatation and systolic dysfunction develop, leading to right heart insufficiency, and ultimately, right heart failure.

Original language	English
Pages (from-to)	53-60
Number of pages	8
Journal	Heart Failure Clinics
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.hfc.2019.08.004
Publication status	Published - Jan 2020

Keywords

Chronic heart failure
Heart failure with preserved ejection fraction
Pulmonary hypertension
Right ventricle

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2019.08.004

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title = "When Pulmonary Hypertension Complicates Heart Failure",

abstract = "Pulmonary hypertension (PH) often complicates chronic left-sided heart failure, with a remarkable impact on quality of life, exercise capacity, and survival. PH in chronic left-sided heart failure (PH-LHD) is not only caused by backward transmission of pressures but also involves impairment of atrial function, inflammation, and vasoconstriction. Once the left atrium loses its reservoir capacity, usually pulmonary vascular resistances increase. Right atrial dilation commonly represents the first sign of PH-LHD, before right ventricle dilatation and systolic dysfunction develop, leading to right heart insufficiency, and ultimately, right heart failure.",

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T1 - When Pulmonary Hypertension Complicates Heart Failure

AU - Marra, Alberto Maria

AU - Benjamin, Nicola

AU - Cittadini, Antonio

AU - Bossone, Eduardo

AU - Grünig, Ekkehard

PY - 2020/1

Y1 - 2020/1

N2 - Pulmonary hypertension (PH) often complicates chronic left-sided heart failure, with a remarkable impact on quality of life, exercise capacity, and survival. PH in chronic left-sided heart failure (PH-LHD) is not only caused by backward transmission of pressures but also involves impairment of atrial function, inflammation, and vasoconstriction. Once the left atrium loses its reservoir capacity, usually pulmonary vascular resistances increase. Right atrial dilation commonly represents the first sign of PH-LHD, before right ventricle dilatation and systolic dysfunction develop, leading to right heart insufficiency, and ultimately, right heart failure.

AB - Pulmonary hypertension (PH) often complicates chronic left-sided heart failure, with a remarkable impact on quality of life, exercise capacity, and survival. PH in chronic left-sided heart failure (PH-LHD) is not only caused by backward transmission of pressures but also involves impairment of atrial function, inflammation, and vasoconstriction. Once the left atrium loses its reservoir capacity, usually pulmonary vascular resistances increase. Right atrial dilation commonly represents the first sign of PH-LHD, before right ventricle dilatation and systolic dysfunction develop, leading to right heart insufficiency, and ultimately, right heart failure.

KW - Chronic heart failure

KW - Heart failure with preserved ejection fraction

KW - Pulmonary hypertension

KW - Right ventricle

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