When should "chronic migraine" patients be considered "refractory" to pharmacological prophylaxis?

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Patients with chronic headache forms evolving from a previous episodic migraine ('chronic migraine') are often difficult to treat. In this paper we focus attention on aspects we believe important for producing a definition of "refractory" in relation to this headache form. We propose a "chronic migraine" patient should be considered "refractory" to pharmacological prophylaxis when adequate trials of preventive therapies at adequate doses have failed to reduce headache frequency and improve headache-related disability and, in patients with medication overuse, reduce the consumption of symptomatic drugs. However before a definition of "refractory" chronic migraine can become established, generally accepted diagnostic criteria and treatment guidelines for this condition need to be developed.

Original languageEnglish
JournalNeurological Sciences
Volume29
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2008

Fingerprint

Migraine Disorders
Pharmacology
Headache
Headache Disorders
Guidelines
Therapeutics
Pharmaceutical Preparations

Keywords

  • Chronic migraine (CM)
  • Prophylaxis
  • Refractory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

When should "chronic migraine" patients be considered "refractory" to pharmacological prophylaxis? / D'Amico, Domenico; Leone, Massimo; Grazzi, Licia; Bussone, Gennaro.

In: Neurological Sciences, Vol. 29, No. SUPPL. 1, 05.2008.

Research output: Contribution to journalArticle

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