Both the sirtuins and certain transcription factors of the NF-κB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-κB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)