When ubiquitin meets ubiquitin receptors: A signalling connection

Pier Paolo Di Fiore, Simona Polo, Kay Hofmann

Research output: Contribution to journalArticlepeer-review

Abstract

Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume4
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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