Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

A Mocroft, K Laut, P Reiss, J Gatell, V Ormaasen, M Cavassini, V Hadziosmanovic, K Mansinho, C Pradier, M Vasylyev, V Mitsura, L Vandekerckhove, L Ostergaard, A Clarke, O Degen, F Mulcahy, A Castagna, Z Sthoeger, L Flamholc, D SedláčekI Mozer-Lisewska, JD Lundgren, for the EuroSIDA Study

Research output: Contribution to journalArticle


Objective: The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown. Method: EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4 + cell count ≤350/μl, viral load ≥10 000 copies/ml), low risk (CD4 + cell count ≥500 cells/μl, viral load <50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events. Results: A total of 16 839 persons were included with 136 688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-To-Three-fold increase in older persons (P = 0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-To-four-fold difference in all other regions (P = 0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P < 0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P = 0.57, 0.060 and 0.090, respectively, interaction). Conclusion: Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care. © Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Original languageEnglish
Pages (from-to)205-215
Number of pages11
Issue number2
Publication statusPublished - 2018

Fingerprint Dive into the research topics of 'Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?'. Together they form a unique fingerprint.

  • Cite this

    Mocroft, A., Laut, K., Reiss, P., Gatell, J., Ormaasen, V., Cavassini, M., Hadziosmanovic, V., Mansinho, K., Pradier, C., Vasylyev, M., Mitsura, V., Vandekerckhove, L., Ostergaard, L., Clarke, A., Degen, O., Mulcahy, F., Castagna, A., Sthoeger, Z., Flamholc, L., ... Study, F. T. EIDA. (2018). Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV? AIDS, 32(2), 205-215. https://doi.org/10.1097/QAD.0000000000001684