Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

A Mocroft, K Laut, P Reiss, J Gatell, V Ormaasen, M Cavassini, V Hadziosmanovic, K Mansinho, C Pradier, M Vasylyev, V Mitsura, L Vandekerckhove, L Ostergaard, A Clarke, O Degen, F Mulcahy, A Castagna, Z Sthoeger, L Flamholc, D SedláčekI Mozer-Lisewska, JD Lundgren, for the EuroSIDA Study

Research output: Contribution to journalArticle

Abstract

Objective: The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown. Method: EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4 + cell count ≤350/μl, viral load ≥10 000 copies/ml), low risk (CD4 + cell count ≥500 cells/μl, viral load <50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events. Results: A total of 16 839 persons were included with 136 688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-To-Three-fold increase in older persons (P = 0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-To-four-fold difference in all other regions (P = 0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P < 0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P = 0.57, 0.060 and 0.090, respectively, interaction). Conclusion: Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care. © Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Original languageEnglish
Pages (from-to)205-215
Number of pages11
JournalAIDS
Volume32
Issue number2
DOIs
Publication statusPublished - 2018

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HIV Infections
Acquired Immunodeficiency Syndrome
HIV
Incidence
CD4 Lymphocyte Count
Viral Load
Eastern Europe
Aftercare
Quality of Health Care
Age Groups
Health

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Mocroft, A., Laut, K., Reiss, P., Gatell, J., Ormaasen, V., Cavassini, M., ... Study, F. T. EIDA. (2018). Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV? AIDS, 32(2), 205-215. https://doi.org/10.1097/QAD.0000000000001684

Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV? / Mocroft, A; Laut, K; Reiss, P; Gatell, J; Ormaasen, V; Cavassini, M; Hadziosmanovic, V; Mansinho, K; Pradier, C; Vasylyev, M; Mitsura, V; Vandekerckhove, L; Ostergaard, L; Clarke, A; Degen, O; Mulcahy, F; Castagna, A; Sthoeger, Z; Flamholc, L; Sedláček, D; Mozer-Lisewska, I; Lundgren, JD; Study, for the EuroSIDA.

In: AIDS, Vol. 32, No. 2, 2018, p. 205-215.

Research output: Contribution to journalArticle

Mocroft, A, Laut, K, Reiss, P, Gatell, J, Ormaasen, V, Cavassini, M, Hadziosmanovic, V, Mansinho, K, Pradier, C, Vasylyev, M, Mitsura, V, Vandekerckhove, L, Ostergaard, L, Clarke, A, Degen, O, Mulcahy, F, Castagna, A, Sthoeger, Z, Flamholc, L, Sedláček, D, Mozer-Lisewska, I, Lundgren, JD & Study, FTEIDA 2018, 'Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?', AIDS, vol. 32, no. 2, pp. 205-215. https://doi.org/10.1097/QAD.0000000000001684
Mocroft, A ; Laut, K ; Reiss, P ; Gatell, J ; Ormaasen, V ; Cavassini, M ; Hadziosmanovic, V ; Mansinho, K ; Pradier, C ; Vasylyev, M ; Mitsura, V ; Vandekerckhove, L ; Ostergaard, L ; Clarke, A ; Degen, O ; Mulcahy, F ; Castagna, A ; Sthoeger, Z ; Flamholc, L ; Sedláček, D ; Mozer-Lisewska, I ; Lundgren, JD ; Study, for the EuroSIDA. / Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?. In: AIDS. 2018 ; Vol. 32, No. 2. pp. 205-215.
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abstract = "Objective: The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown. Method: EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4 + cell count ≤350/μl, viral load ≥10 000 copies/ml), low risk (CD4 + cell count ≥500 cells/μl, viral load <50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events. Results: A total of 16 839 persons were included with 136 688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-To-Three-fold increase in older persons (P = 0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-To-four-fold difference in all other regions (P = 0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P < 0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P = 0.57, 0.060 and 0.090, respectively, interaction). Conclusion: Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care. {\circledC} Copyright {\circledC} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
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T1 - Where is the greatest impact of uncontrolled HIV infection on AIDS and non-AIDS events in HIV?

AU - Mocroft, A

AU - Laut, K

AU - Reiss, P

AU - Gatell, J

AU - Ormaasen, V

AU - Cavassini, M

AU - Hadziosmanovic, V

AU - Mansinho, K

AU - Pradier, C

AU - Vasylyev, M

AU - Mitsura, V

AU - Vandekerckhove, L

AU - Ostergaard, L

AU - Clarke, A

AU - Degen, O

AU - Mulcahy, F

AU - Castagna, A

AU - Sthoeger, Z

AU - Flamholc, L

AU - Sedláček, D

AU - Mozer-Lisewska, I

AU - Lundgren, JD

AU - Study, for the EuroSIDA

PY - 2018

Y1 - 2018

N2 - Objective: The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown. Method: EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4 + cell count ≤350/μl, viral load ≥10 000 copies/ml), low risk (CD4 + cell count ≥500 cells/μl, viral load <50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events. Results: A total of 16 839 persons were included with 136 688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-To-Three-fold increase in older persons (P = 0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-To-four-fold difference in all other regions (P = 0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P < 0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P = 0.57, 0.060 and 0.090, respectively, interaction). Conclusion: Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care. © Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

AB - Objective: The extent to which controlled and uncontrolled HIV interact with ageing, European region of care and calendar year of follow-up is largely unknown. Method: EuroSIDA participants were followed after 1 January 2001 and grouped according to current HIV progression risk; high risk (CD4 + cell count ≤350/μl, viral load ≥10 000 copies/ml), low risk (CD4 + cell count ≥500 cells/μl, viral load <50 copies/ml) and intermediate (other combinations). Poisson regression investigated interactions between HIV progression risk, age, European region of care and year of follow-up and incidence of AIDS or non-AIDS events. Results: A total of 16 839 persons were included with 136 688 person-years of follow-up. In persons aged 30 years or less, those at high risk had a six-fold increased incidence of non-AIDS compared with those at low risk, compared with a two-To-Three-fold increase in older persons (P = 0.0004, interaction). In Eastern Europe, those at highest risk of non-AIDS had a 12-fold increased incidence compared with a two-To-four-fold difference in all other regions (P = 0.0029, interaction). Those at high risk of non-AIDS during 2001-2004 had a two-fold increased incidence compared with those at low risk, increasing to a five-fold increase between 2013 and 2016 (P < 0.0001, interaction). Differences among high, intermediate and low risk of AIDS were similar across age groups, year of follow-up and Europe (P = 0.57, 0.060 and 0.090, respectively, interaction). Conclusion: Factors other than optimal control of HIV become increasingly important with ageing for predicting non-AIDS, whereas differences across Europe reflect differences in patient management as well as underlying socioeconomic circumstances. The differences between those at high, intermediate and low risk of non-AIDS between 2013 and 2016 likely reflects better quality of care. © Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

U2 - 10.1097/QAD.0000000000001684

DO - 10.1097/QAD.0000000000001684

M3 - Article

VL - 32

SP - 205

EP - 215

JO - AIDS

JF - AIDS

SN - 0269-9370

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