Which tools may help physicians in female fertility prediction after autologous bone marrow transplantation for lymphoma? A pilot study

Lino Del Pup, Ernesto Zanet, Maurizio Rupolo, Renato Talamini, Umberto Tirelli, Mario Mazzucato, Agostino Steffan, Stefania Zanussi, Paolo Doretto, Mariagrazia Michieli

Research output: Contribution to journalArticle


Objective(s): The report of our experience on fertility preservation and the validation of some tools useful to predict fertility in young females who underwent haematopoietic cell transplantation for their lymphoma.

Study design: A retrospective study involving 17 consecutive women of child-bearing age affected by lymphoma and submitted to haematopoietic cell transplantation in our centre.

Results: We described a high rate of parenthood in our patient series: 5 out of 17 (29%) patients became pregnant and 1 out of 5 had two pregnancies. It is suggestive that only patients who received gonadotropin-releasing hormone (GnRH) analogues co-treatment conceaved. Antral follicles number or ovarian volume, ascertained through transvaginal ultrasound before starting treatment, more than anti-Mullerian hormone (AMH) value, are tools that may help physicians to better predict fertility in young females of child-bearing age affected by lymphoma who desire to get pregnant after cancer cares.

Conclusion(s): The high rate of maternity we recorded may lead to comfort the young women who hope to become pregnant after cancer cares because pregnancy is possible in a certain percentage of cases even after highly toxic treatments to the ovaries. A higher ovarian volume or a higher number of antral follicles, before treatment start, ensures a greater chance of successful pregnancies. AMH value in lymphoma survivors is not sufficient to guide physicians in fertility predictions.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalJournal of Chemotherapy
Issue number5
Publication statusPublished - Oct 1 2014



  • Anti-Mullerian hormone
  • Cancer survivorship
  • Fertility
  • Haematopoietic cell transplantation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology
  • Medicine(all)

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