Whipworm kinomes reflect a unique biology and adaptation to the host animal

Andreas J. Stroehlein, Neil D. Young, Pasi K. Korhonen, Bill C.H. Chang, Peter Nejsum, Edoardo Pozio, Giuseppe La Rosa, Paul W. Sternberg, Robin B. Gasser

Research output: Contribution to journalArticle

Abstract

Roundworms belong to a diverse phylum (Nematoda) which is comprised of many parasitic species including whipworms (genus Trichuris). These worms have adapted to a biological niche within the host and exhibit unique morphological characteristics compared with other nematodes. Although these adaptations are known, the underlying molecular mechanisms remain elusive. The availability of genomes and transcriptomes of some whipworms now enables detailed studies of their molecular biology. Here, we defined and curated the full complement of an important class of enzymes, the protein kinases (kinomes) of two species of Trichuris, using an advanced and integrated bioinformatic pipeline. We investigated the transcription of Trichuris suis kinase genes across developmental stages, sexes and tissues, and reveal that selectively transcribed genes can be linked to central roles in developmental and reproductive processes. We also classified and functionally annotated the curated kinomes by integrating evidence from structural modelling and pathway analyses, and compared them with other curated kinomes of phylogenetically diverse nematode species. Our findings suggest unique adaptations in signalling processes governing worm morphology and biology, and provide an important resource that should facilitate experimental investigations of kinases and the biology of signalling pathways in nematodes.

Original languageEnglish
Pages (from-to)857-866
Number of pages10
JournalInternational Journal for Parasitology
Volume47
Issue number13
DOIs
Publication statusPublished - Nov 1 2017

Keywords

  • Gene curation
  • Host–parasite interactions
  • Kinase signalling
  • Kinome
  • Nematodes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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  • Cite this

    Stroehlein, A. J., Young, N. D., Korhonen, P. K., Chang, B. C. H., Nejsum, P., Pozio, E., La Rosa, G., Sternberg, P. W., & Gasser, R. B. (2017). Whipworm kinomes reflect a unique biology and adaptation to the host animal. International Journal for Parasitology, 47(13), 857-866. https://doi.org/10.1016/j.ijpara.2017.04.005