White matter abnormalities in adolescent-onset and adult-onset schizophrenia: New directions in research

Ilaria Spoletini, Gianfranco Spalletta

Research output: Contribution to journalArticlepeer-review

Abstract

Evaluation of: Kyriakopoulos M, Perez-Iglesias R, Woolley JB et al.: Effect of age at onset of schizophrenia on white matter abnormalities. Br. J. Psychiatry 195(4), 346-353 (2009). This study demonstrated that brain white matter abnormalities in schizophrenia may depend on developmental stage at the time of the illness. The authors reported different patterns of fractional anisotropy reductions in adolescent-onset compared with adult-onset schizophrenia. In addition, the effect of schizophrenia on fractional anisotropy is modulated by age-at-onset in bilateral prefrontal white matter. These white matter abnormalities appear to mirror the progression of gray matter volume deficits described in previous research. This study raises important questions regarding the progression of such abnormalities and highlights the need for longitudinal studies to investigate the staging of the appearance of structural and connectivity brain abnormalities in schizophrenia.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalFuture Neurology
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 2010

Keywords

  • DTI
  • Fractional anisotropy
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'White matter abnormalities in adolescent-onset and adult-onset schizophrenia: New directions in research'. Together they form a unique fingerprint.

Cite this