White matter alterations in early Parkinson’s disease: role of motor symptom lateralization

Research output: Contribution to journalArticle

Abstract

Introduction: Parkinson’s disease (PD) is a motor disorder that initially presents with unilateral symptoms. Widespread white matter (WM) alterations have been reported since the early stages of the disease. The aim of this study was to investigate WM alterations in right-dominant and left-dominant symptom PD patients (RPD and LPD, respectively) with respect to healthy controls (HC) by diffusion-weighted magnetic resonance imaging (MRI). Methods: Thirty-eight subjects participated in this study: 12 RPD (median H&Y [IQR] = 1.5 [1.1–2], median UPDRS III [IQR] = 23 [7.8–25]), 9 LPD (median H&Y [IQR] = 1.5 [1–2.5], median UPDRS III [IQR] = 17 [12–22]), and 17 HC. All the participants were scanned on a 1.5-T MRI scanner. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were computed for all the subjects. Tract-based spatial statistics (TBSS) was performed for each diffusion parameter, to test WM differences between RPD, LPD, and HC (ANCOVA design). Family-wise error (FWE) correction was performed and p values lower than 0.05 were considered significant. Results: No significant FA and RD differences were observed between RPD, LPD, and HC. Significantly increased MD and AD were observed in RPD with respect to HC within widespread WM regions, bilaterally. Conversely, no significant WM alterations were detected in LPD. Conclusion: WM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.

Original languageEnglish
JournalNeurological Sciences
DOIs
Publication statusE-pub ahead of print - Oct 24 2019

Fingerprint

Parkinson Disease
Anisotropy
Diffusion Magnetic Resonance Imaging
White Matter
Neuroimaging
Magnetic Resonance Imaging

Keywords

  • Clinical laterality onset
  • Diffusion tensor MRI
  • Parkinson’s disease
  • TBSS
  • White matter
  • White matter alterations

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

@article{9570a5ad98dd4aa4b4ea40d1cedf36ed,
title = "White matter alterations in early Parkinson’s disease: role of motor symptom lateralization",
abstract = "Introduction: Parkinson’s disease (PD) is a motor disorder that initially presents with unilateral symptoms. Widespread white matter (WM) alterations have been reported since the early stages of the disease. The aim of this study was to investigate WM alterations in right-dominant and left-dominant symptom PD patients (RPD and LPD, respectively) with respect to healthy controls (HC) by diffusion-weighted magnetic resonance imaging (MRI). Methods: Thirty-eight subjects participated in this study: 12 RPD (median H&Y [IQR] = 1.5 [1.1–2], median UPDRS III [IQR] = 23 [7.8–25]), 9 LPD (median H&Y [IQR] = 1.5 [1–2.5], median UPDRS III [IQR] = 17 [12–22]), and 17 HC. All the participants were scanned on a 1.5-T MRI scanner. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were computed for all the subjects. Tract-based spatial statistics (TBSS) was performed for each diffusion parameter, to test WM differences between RPD, LPD, and HC (ANCOVA design). Family-wise error (FWE) correction was performed and p values lower than 0.05 were considered significant. Results: No significant FA and RD differences were observed between RPD, LPD, and HC. Significantly increased MD and AD were observed in RPD with respect to HC within widespread WM regions, bilaterally. Conversely, no significant WM alterations were detected in LPD. Conclusion: WM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.",
keywords = "Clinical laterality onset, Diffusion tensor MRI, Parkinson’s disease, TBSS, White matter, White matter alterations",
author = "Laura Pelizzari and {Di Tella}, Sonia and Lagan{\`a}, {Maria M.} and Niels Bergsland and Federica Rossetto and Raffaello Nemni and Francesca Baglio",
year = "2019",
month = "10",
day = "24",
doi = "10.1007/s10072-019-04084-y",
language = "English",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",

}

TY - JOUR

T1 - White matter alterations in early Parkinson’s disease

T2 - role of motor symptom lateralization

AU - Pelizzari, Laura

AU - Di Tella, Sonia

AU - Laganà, Maria M.

AU - Bergsland, Niels

AU - Rossetto, Federica

AU - Nemni, Raffaello

AU - Baglio, Francesca

PY - 2019/10/24

Y1 - 2019/10/24

N2 - Introduction: Parkinson’s disease (PD) is a motor disorder that initially presents with unilateral symptoms. Widespread white matter (WM) alterations have been reported since the early stages of the disease. The aim of this study was to investigate WM alterations in right-dominant and left-dominant symptom PD patients (RPD and LPD, respectively) with respect to healthy controls (HC) by diffusion-weighted magnetic resonance imaging (MRI). Methods: Thirty-eight subjects participated in this study: 12 RPD (median H&Y [IQR] = 1.5 [1.1–2], median UPDRS III [IQR] = 23 [7.8–25]), 9 LPD (median H&Y [IQR] = 1.5 [1–2.5], median UPDRS III [IQR] = 17 [12–22]), and 17 HC. All the participants were scanned on a 1.5-T MRI scanner. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were computed for all the subjects. Tract-based spatial statistics (TBSS) was performed for each diffusion parameter, to test WM differences between RPD, LPD, and HC (ANCOVA design). Family-wise error (FWE) correction was performed and p values lower than 0.05 were considered significant. Results: No significant FA and RD differences were observed between RPD, LPD, and HC. Significantly increased MD and AD were observed in RPD with respect to HC within widespread WM regions, bilaterally. Conversely, no significant WM alterations were detected in LPD. Conclusion: WM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.

AB - Introduction: Parkinson’s disease (PD) is a motor disorder that initially presents with unilateral symptoms. Widespread white matter (WM) alterations have been reported since the early stages of the disease. The aim of this study was to investigate WM alterations in right-dominant and left-dominant symptom PD patients (RPD and LPD, respectively) with respect to healthy controls (HC) by diffusion-weighted magnetic resonance imaging (MRI). Methods: Thirty-eight subjects participated in this study: 12 RPD (median H&Y [IQR] = 1.5 [1.1–2], median UPDRS III [IQR] = 23 [7.8–25]), 9 LPD (median H&Y [IQR] = 1.5 [1–2.5], median UPDRS III [IQR] = 17 [12–22]), and 17 HC. All the participants were scanned on a 1.5-T MRI scanner. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were computed for all the subjects. Tract-based spatial statistics (TBSS) was performed for each diffusion parameter, to test WM differences between RPD, LPD, and HC (ANCOVA design). Family-wise error (FWE) correction was performed and p values lower than 0.05 were considered significant. Results: No significant FA and RD differences were observed between RPD, LPD, and HC. Significantly increased MD and AD were observed in RPD with respect to HC within widespread WM regions, bilaterally. Conversely, no significant WM alterations were detected in LPD. Conclusion: WM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.

KW - Clinical laterality onset

KW - Diffusion tensor MRI

KW - Parkinson’s disease

KW - TBSS

KW - White matter

KW - White matter alterations

UR - http://www.scopus.com/inward/record.url?scp=85074592465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074592465&partnerID=8YFLogxK

U2 - 10.1007/s10072-019-04084-y

DO - 10.1007/s10072-019-04084-y

M3 - Article

C2 - 31650438

AN - SCOPUS:85074592465

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

ER -