White matter damage in frontotemporal lobar degeneration spectrum

F. Agosta, E. Scola, E. Canu, A. Marcone, G. Magnani, L. Sarro, M. Copetti, F. Caso, C. Cerami, G. Comi, S. F. Cappa, A. Falini, M. Filippi

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

White matter (WM) tract damage was assessed in patients with the behavioral variant frontotemporal dementia (bvFTD) and the 3 primary progressive aphasia (PPA) variants and compared with the corresponding brain atrophy patterns. Thirteen bvFTD and 20 PPA patients were studied. Tract-based spatial statistics and voxel-based morphometry were used. Patients with bvFTD showed widespread diffusion tensor magnetic resonance imaging (DT MRI) abnormalities affecting most of the WM bilaterally. In PPA patients, WM damage was more focal and varied across the 3 syndromes: left frontotemporoparietal in nonfluent, left frontotemporal in semantic, and left frontoparietal in logopenic patients. In each syndrome, DT MRI changes extended beyond the topography of gray matter loss. Left uncinate damage was the best predictor of frontotemporal lobar degeneration diagnosis versus controls. DT MRI measures of the anterior corpus callosum and left superior longitudinal fasciculus differentiated bvFTD from nonfluent cases. The best predictors of semantic PPA compared with both bvFTD and nonfluent cases were diffusivity abnormalities of the left uncinate and inferior longitudinal fasciculus. This study provides insights into the similarities and differences of WM damage in bvFTD and PPA variants. DT MRI metrics hold promise to serve as early markers of WM integrity loss that only at a later stage may be detectable by volumetric measures.

Original languageEnglish
Pages (from-to)2705-2714
Number of pages10
JournalCerebral Cortex
Volume22
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Frontotemporal Lobar Degeneration
Primary Progressive Aphasia
Frontotemporal Dementia
Diffusion Magnetic Resonance Imaging
Semantics
Corpus Callosum
Atrophy
White Matter
Brain

Keywords

  • diffusion tensor MRI
  • frontotemporal dementia
  • frontotemporal lobar degeneration
  • primary progressive aphasia
  • white matter

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

White matter damage in frontotemporal lobar degeneration spectrum. / Agosta, F.; Scola, E.; Canu, E.; Marcone, A.; Magnani, G.; Sarro, L.; Copetti, M.; Caso, F.; Cerami, C.; Comi, G.; Cappa, S. F.; Falini, A.; Filippi, M.

In: Cerebral Cortex, Vol. 22, No. 12, 12.2012, p. 2705-2714.

Research output: Contribution to journalArticle

Agosta, F. ; Scola, E. ; Canu, E. ; Marcone, A. ; Magnani, G. ; Sarro, L. ; Copetti, M. ; Caso, F. ; Cerami, C. ; Comi, G. ; Cappa, S. F. ; Falini, A. ; Filippi, M. / White matter damage in frontotemporal lobar degeneration spectrum. In: Cerebral Cortex. 2012 ; Vol. 22, No. 12. pp. 2705-2714.
@article{2836abd4a4a348c78638dc4b3b83217d,
title = "White matter damage in frontotemporal lobar degeneration spectrum",
abstract = "White matter (WM) tract damage was assessed in patients with the behavioral variant frontotemporal dementia (bvFTD) and the 3 primary progressive aphasia (PPA) variants and compared with the corresponding brain atrophy patterns. Thirteen bvFTD and 20 PPA patients were studied. Tract-based spatial statistics and voxel-based morphometry were used. Patients with bvFTD showed widespread diffusion tensor magnetic resonance imaging (DT MRI) abnormalities affecting most of the WM bilaterally. In PPA patients, WM damage was more focal and varied across the 3 syndromes: left frontotemporoparietal in nonfluent, left frontotemporal in semantic, and left frontoparietal in logopenic patients. In each syndrome, DT MRI changes extended beyond the topography of gray matter loss. Left uncinate damage was the best predictor of frontotemporal lobar degeneration diagnosis versus controls. DT MRI measures of the anterior corpus callosum and left superior longitudinal fasciculus differentiated bvFTD from nonfluent cases. The best predictors of semantic PPA compared with both bvFTD and nonfluent cases were diffusivity abnormalities of the left uncinate and inferior longitudinal fasciculus. This study provides insights into the similarities and differences of WM damage in bvFTD and PPA variants. DT MRI metrics hold promise to serve as early markers of WM integrity loss that only at a later stage may be detectable by volumetric measures.",
keywords = "diffusion tensor MRI, frontotemporal dementia, frontotemporal lobar degeneration, primary progressive aphasia, white matter",
author = "F. Agosta and E. Scola and E. Canu and A. Marcone and G. Magnani and L. Sarro and M. Copetti and F. Caso and C. Cerami and G. Comi and Cappa, {S. F.} and A. Falini and M. Filippi",
year = "2012",
month = "12",
doi = "10.1093/cercor/bhr288",
language = "English",
volume = "22",
pages = "2705--2714",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - White matter damage in frontotemporal lobar degeneration spectrum

AU - Agosta, F.

AU - Scola, E.

AU - Canu, E.

AU - Marcone, A.

AU - Magnani, G.

AU - Sarro, L.

AU - Copetti, M.

AU - Caso, F.

AU - Cerami, C.

AU - Comi, G.

AU - Cappa, S. F.

AU - Falini, A.

AU - Filippi, M.

PY - 2012/12

Y1 - 2012/12

N2 - White matter (WM) tract damage was assessed in patients with the behavioral variant frontotemporal dementia (bvFTD) and the 3 primary progressive aphasia (PPA) variants and compared with the corresponding brain atrophy patterns. Thirteen bvFTD and 20 PPA patients were studied. Tract-based spatial statistics and voxel-based morphometry were used. Patients with bvFTD showed widespread diffusion tensor magnetic resonance imaging (DT MRI) abnormalities affecting most of the WM bilaterally. In PPA patients, WM damage was more focal and varied across the 3 syndromes: left frontotemporoparietal in nonfluent, left frontotemporal in semantic, and left frontoparietal in logopenic patients. In each syndrome, DT MRI changes extended beyond the topography of gray matter loss. Left uncinate damage was the best predictor of frontotemporal lobar degeneration diagnosis versus controls. DT MRI measures of the anterior corpus callosum and left superior longitudinal fasciculus differentiated bvFTD from nonfluent cases. The best predictors of semantic PPA compared with both bvFTD and nonfluent cases were diffusivity abnormalities of the left uncinate and inferior longitudinal fasciculus. This study provides insights into the similarities and differences of WM damage in bvFTD and PPA variants. DT MRI metrics hold promise to serve as early markers of WM integrity loss that only at a later stage may be detectable by volumetric measures.

AB - White matter (WM) tract damage was assessed in patients with the behavioral variant frontotemporal dementia (bvFTD) and the 3 primary progressive aphasia (PPA) variants and compared with the corresponding brain atrophy patterns. Thirteen bvFTD and 20 PPA patients were studied. Tract-based spatial statistics and voxel-based morphometry were used. Patients with bvFTD showed widespread diffusion tensor magnetic resonance imaging (DT MRI) abnormalities affecting most of the WM bilaterally. In PPA patients, WM damage was more focal and varied across the 3 syndromes: left frontotemporoparietal in nonfluent, left frontotemporal in semantic, and left frontoparietal in logopenic patients. In each syndrome, DT MRI changes extended beyond the topography of gray matter loss. Left uncinate damage was the best predictor of frontotemporal lobar degeneration diagnosis versus controls. DT MRI measures of the anterior corpus callosum and left superior longitudinal fasciculus differentiated bvFTD from nonfluent cases. The best predictors of semantic PPA compared with both bvFTD and nonfluent cases were diffusivity abnormalities of the left uncinate and inferior longitudinal fasciculus. This study provides insights into the similarities and differences of WM damage in bvFTD and PPA variants. DT MRI metrics hold promise to serve as early markers of WM integrity loss that only at a later stage may be detectable by volumetric measures.

KW - diffusion tensor MRI

KW - frontotemporal dementia

KW - frontotemporal lobar degeneration

KW - primary progressive aphasia

KW - white matter

UR - http://www.scopus.com/inward/record.url?scp=84869027954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869027954&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhr288

DO - 10.1093/cercor/bhr288

M3 - Article

C2 - 21988828

AN - SCOPUS:84869027954

VL - 22

SP - 2705

EP - 2714

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 12

ER -