TY - JOUR
T1 - White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment
T2 - The DESCRIPA study
AU - Van De Pol, Laura A.
AU - Verhey, F.
AU - Frisoni, G. B.
AU - Tsolaki, M.
AU - Papapostolou, P.
AU - Nobili, F.
AU - Wahlund, L. O.
AU - Minthon, L.
AU - Frölich, L.
AU - Hampel, H.
AU - Soininen, H.
AU - Knol, D. L.
AU - Barkhof, F.
AU - Scheltens, P.
AU - Visser, P. J.
PY - 2009/10
Y1 - 2009/10
N2 - Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0-4) and white matter hyperintensities (WMH) (0-30) were assessed. Results: Severity of MTA differed between MCI subtypes (p70 years of age. Severity of WMH did not differ between MCI subtypes (p = 0.21). However, the combination of MTA and WMH differed between MCI subtypes (p = 0.02) Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.
AB - Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0-4) and white matter hyperintensities (WMH) (0-30) were assessed. Results: Severity of MTA differed between MCI subtypes (p70 years of age. Severity of WMH did not differ between MCI subtypes (p = 0.21). However, the combination of MTA and WMH differed between MCI subtypes (p = 0.02) Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.
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U2 - 10.1136/jnnp.2008.158881
DO - 10.1136/jnnp.2008.158881
M3 - Article
C2 - 19541689
AN - SCOPUS:70349653652
VL - 80
SP - 1069
EP - 1074
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 10
ER -