White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: The DESCRIPA study

Laura A. Van De Pol, F. Verhey, G. B. Frisoni, M. Tsolaki, P. Papapostolou, F. Nobili, L. O. Wahlund, L. Minthon, L. Frölich, H. Hampel, H. Soininen, D. L. Knol, F. Barkhof, P. Scheltens, P. J. Visser

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies. Methods: This European, multicentre, memory clinic based study (DESCRIPA) of non-demented subjects investigated whether MCI subtypes have different brain correlates on MRI and whether the relation between subtypes and brain pathology is modified by age. Using visual rating scales, medial temporal lobe atrophy (MTA) (0-4) and white matter hyperintensities (WMH) (0-30) were assessed. Results: Severity of MTA differed between MCI subtypes (p70 years of age. Severity of WMH did not differ between MCI subtypes (p = 0.21). However, the combination of MTA and WMH differed between MCI subtypes (p = 0.02) Conclusion: We conclude that MCI subtypes may have different brain substrates, especially in older subjects. Isolated MTA was mainly associated with amnestic MCI subtypes, suggesting AD as the underlying cause. In non-amnestic MCI, the relatively higher prevalence of MTA in combination with WMH may suggest a different pathophysiological origin.

Original languageEnglish
Pages (from-to)1069-1074
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume80
Issue number10
DOIs
Publication statusPublished - Oct 2009

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

Fingerprint Dive into the research topics of 'White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: The DESCRIPA study'. Together they form a unique fingerprint.

Cite this