White matter hyperintensities on brain magnetic resonance in systemic sclerosis

F. Sardanelli, A. Iozzelli, B. Cotticelli, C. Losacco, M. Cutolo, A. Sulli, F. Nobili, G. Rodriguez

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the brain status of patients with systemic sclerosis (SSc). Methods: Fourteen female patients with SSc aged 24-74, with a disease duration of 1-12 years and without other relevant systemic diseases, were enrolled. All patients and an age matched female control group (CG) of 14 clinically normal subjects, underwent brain magnetic resonance examination at 1.5 T; spin echo proton density weighted images were evaluated. Mann-Whitney U and Spearman rank correlation tests were used for statistical analysis. Results: 170 white matter hyperintensities ≥2 mm in diameter were counted in the patient group (range 0-75, mean 12.1, median 4.5), only 13 in the CG (0-2, 0.9, 1, respectively), with a significant difference (p = 0.011). Moreover, 208 white matter hyperintensities

Original languageEnglish
Pages (from-to)777-779
Number of pages3
JournalAnnals of the Rheumatic Diseases
Issue number5
Publication statusPublished - May 2005

ASJC Scopus subject areas

  • Rheumatology
  • Immunology


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