White-matter lesions along the cholinergic tracts are related to cortical sources of eeg rhythms in amnesic mild cognitive impairment

Claudio Babiloni, Michela Pievani, Fabrizio Vecchio, Cristina Geroldi, Fabrizio Eusebi, Claudia Fracassi, Evan Fletcher, Charles De Carli, Marina Boccardi, Paolo Maria Rossini, Giovanni B. Frisoni

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Abstract

Abstract: Does impairment of cholinergic systems represent an important factor in the development of amnesic mild cognitive impairment (aMCI), as a preclinical stage of Alzheimer's disease (AD)? Here we tested the hypothesis that electroencephalographic (EEG) rhythms, known to be modulated by the cholinergic system, may be particularly affected in aMCI patients with lesions along the cholinergic white-matter tracts. Eyes-closed resting EEG data were recorded in 28 healthy elderly (Nold) and 57 aMCI patients. Lesions along the cholinergic white-matter tracts were detected with fluid-attenuated inversion recovery sequences on magnetic resonance imaging. The estimation of the cholinergic lesion was performed with a validated semi-automatic algorithm pipeline after registration to a stereotactic template, image integration with stereotactic masks of the cholinergic tracts, and normalization to intracranial volume. The aMCI patients were divided into two groups of high (MCI Ch1; N 5 29; MMSE 5 26.2) and low cholinergic damage (MCI Ch2; N 5 28; MMSE 5 26.6). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG generators were estimated by LORETA software. As main results, (i) power of occipital, parietal, temporal, and limbic alpha 1 sources was maximum in Nold, intermediate in MCI Ch2, and low in MCI Ch1 patients; (ii) the same trend was true in theta sources. These results are consistent with the hypothesis that damage to the cholinergic system is associated with alterations of EEG sources in aMCI subjects. Hum Brain Mapp 30:1431-1443, 2009. VVC 2008 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)1431-1443
Number of pages13
JournalHuman Brain Mapping
Volume30
Issue number5
DOIs
Publication statusPublished - May 2009

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Keywords

  • Alzheimer's disease (AD)
  • Amnesic mild cognitive impairment (aMCI)
  • Cholinergic system
  • Electroencephalography (EEG)
  • Magnetic resonance imaging (MRI)
  • White-matter vascular lesion

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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