TY - JOUR
T1 - White matter metabolism differentiates schizophrenia and bipolar disorder
T2 - A preliminary PET study
AU - Altamura, Alfredo Carlo
AU - Bertoldo, Alessandra
AU - Marotta, Giorgio
AU - Paoli, Riccardo Augusto
AU - Caletti, Elisabetta
AU - Dragogna, Filippo
AU - Buoli, Massimiliano
AU - Baglivo, Valentina
AU - Mauri, Massimo Carlo
AU - Brambilla, Paolo
PY - 2013/12/30
Y1 - 2013/12/30
N2 - Fluorodeoxyglucose-F18 positron emission tomography studies (FDG-PET) have shown similar corticolimbic metabolic dysregulation in bipolar disorder and schizophrenia, with hypoactive prefrontal cortex coupled with hyperactive anterior limbic areas. However, it is not clear whether white matter metabolism connecting these regions is differently affected in the two disorders. Twenty-six patients with schizophrenia (mean age±S.D=30.23±9.7 year-old; 19 males; mean weight±S.D.=71±3. kg) and 26 patients with bipolar disorder (mean age±S.D.=48.73±13 year-old; 18 males; mean weight±S.D.=75±15. kg) underwent an FDG-PET scan. Normalized datasets the two groups of patients were compared on a voxel-by-voxel basis using a two-sample t statistic test as implemented in SPM8, and adding age as covariate. Group differences were assessed applying a threshold of p
AB - Fluorodeoxyglucose-F18 positron emission tomography studies (FDG-PET) have shown similar corticolimbic metabolic dysregulation in bipolar disorder and schizophrenia, with hypoactive prefrontal cortex coupled with hyperactive anterior limbic areas. However, it is not clear whether white matter metabolism connecting these regions is differently affected in the two disorders. Twenty-six patients with schizophrenia (mean age±S.D=30.23±9.7 year-old; 19 males; mean weight±S.D.=71±3. kg) and 26 patients with bipolar disorder (mean age±S.D.=48.73±13 year-old; 18 males; mean weight±S.D.=75±15. kg) underwent an FDG-PET scan. Normalized datasets the two groups of patients were compared on a voxel-by-voxel basis using a two-sample t statistic test as implemented in SPM8, and adding age as covariate. Group differences were assessed applying a threshold of p
KW - Brain activity
KW - Cerebellum
KW - Connectivity
KW - Limbic structures
KW - Prefrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=84888305621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888305621&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2013.08.011
DO - 10.1016/j.pscychresns.2013.08.011
M3 - Article
C2 - 24144506
AN - SCOPUS:84888305621
VL - 214
SP - 410
EP - 414
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
IS - 3
ER -