White matter metabolism differentiates schizophrenia and bipolar disorder: A preliminary PET study

Alfredo Carlo Altamura, Alessandra Bertoldo, Giorgio Marotta, Riccardo Augusto Paoli, Elisabetta Caletti, Filippo Dragogna, Massimiliano Buoli, Valentina Baglivo, Massimo Carlo Mauri, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review

Abstract

Fluorodeoxyglucose-F18 positron emission tomography studies (FDG-PET) have shown similar corticolimbic metabolic dysregulation in bipolar disorder and schizophrenia, with hypoactive prefrontal cortex coupled with hyperactive anterior limbic areas. However, it is not clear whether white matter metabolism connecting these regions is differently affected in the two disorders. Twenty-six patients with schizophrenia (mean age±S.D=30.23±9.7 year-old; 19 males; mean weight±S.D.=71±3. kg) and 26 patients with bipolar disorder (mean age±S.D.=48.73±13 year-old; 18 males; mean weight±S.D.=75±15. kg) underwent an FDG-PET scan. Normalized datasets the two groups of patients were compared on a voxel-by-voxel basis using a two-sample t statistic test as implemented in SPM8, and adding age as covariate. Group differences were assessed applying a threshold of p

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume214
Issue number3
DOIs
Publication statusPublished - Dec 30 2013

Keywords

  • Brain activity
  • Cerebellum
  • Connectivity
  • Limbic structures
  • Prefrontal cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

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