White matter microstructural damage in alzheimer's disease at different ages of onset

Elisa Canu, Federica Agosta, Edoardo G. Spinelli, Giuseppe Magnani, Alessandra Marcone, Elisa Scola, Monica Falautano, Giancarlo Comi, Andrea Falini, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups.

Original languageEnglish
Pages (from-to)2331-2340
Number of pages10
JournalNeurobiology of Aging
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Age of Onset
Alzheimer Disease
Corpus Callosum
Anisotropy
White Matter
Atrophy
Magnetic Resonance Spectroscopy

Keywords

  • Diffusion tensor MRI
  • Early-onset Alzheimer's disease
  • Late-onset Alzheimer's disease
  • MRI
  • White matter damage

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

White matter microstructural damage in alzheimer's disease at different ages of onset. / Canu, Elisa; Agosta, Federica; Spinelli, Edoardo G.; Magnani, Giuseppe; Marcone, Alessandra; Scola, Elisa; Falautano, Monica; Comi, Giancarlo; Falini, Andrea; Filippi, Massimo.

In: Neurobiology of Aging, Vol. 34, No. 10, 10.2013, p. 2331-2340.

Research output: Contribution to journalArticle

Canu, Elisa ; Agosta, Federica ; Spinelli, Edoardo G. ; Magnani, Giuseppe ; Marcone, Alessandra ; Scola, Elisa ; Falautano, Monica ; Comi, Giancarlo ; Falini, Andrea ; Filippi, Massimo. / White matter microstructural damage in alzheimer's disease at different ages of onset. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 10. pp. 2331-2340.
@article{d254731a53f24e4b8441b1a0efd7ccb5,
title = "White matter microstructural damage in alzheimer's disease at different ages of onset",
abstract = "White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups.",
keywords = "Diffusion tensor MRI, Early-onset Alzheimer's disease, Late-onset Alzheimer's disease, MRI, White matter damage",
author = "Elisa Canu and Federica Agosta and Spinelli, {Edoardo G.} and Giuseppe Magnani and Alessandra Marcone and Elisa Scola and Monica Falautano and Giancarlo Comi and Andrea Falini and Massimo Filippi",
year = "2013",
month = "10",
doi = "10.1016/j.neurobiolaging.2013.03.026",
language = "English",
volume = "34",
pages = "2331--2340",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - White matter microstructural damage in alzheimer's disease at different ages of onset

AU - Canu, Elisa

AU - Agosta, Federica

AU - Spinelli, Edoardo G.

AU - Magnani, Giuseppe

AU - Marcone, Alessandra

AU - Scola, Elisa

AU - Falautano, Monica

AU - Comi, Giancarlo

AU - Falini, Andrea

AU - Filippi, Massimo

PY - 2013/10

Y1 - 2013/10

N2 - White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups.

AB - White matter (WM) microstructural damage and its relationship with cortical abnormalities were explored in early-onset Alzheimer's disease (EOAD) compared with late-onset AD (LOAD) patients. Structural and diffusion tensor magnetic resonance images were obtained from 22 EOAD patients, 35 LOAD patients, and 40 healthy controls. Patterns of WM microstructural damage and cortical atrophy, as well as their relationships, were assessed using tract-based spatial statistics, tractography and voxel-based morphometry. Compared with LOAD, EOAD patients had a more severe and distributed pattern of WM microstructural damage, in particular in the posterior fibers of cingulum and corpus callosum. In both groups with Alzheimer's disease, but especially in LOAD patients, correlations between cingulum and corpus callosum fractional anisotropy and parietal, temporal, and frontal cortical volumes were found. In conclusion, WM microstructural damage is more severe in EOAD compared with LOAD patients. Such damage follows different patterns of topographical distribution in the 2 patient groups.

KW - Diffusion tensor MRI

KW - Early-onset Alzheimer's disease

KW - Late-onset Alzheimer's disease

KW - MRI

KW - White matter damage

UR - http://www.scopus.com/inward/record.url?scp=84879889389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879889389&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2013.03.026

DO - 10.1016/j.neurobiolaging.2013.03.026

M3 - Article

C2 - 23623599

AN - SCOPUS:84879889389

VL - 34

SP - 2331

EP - 2340

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 10

ER -