White matter microstructure alterations in bipolar disorder

Marcella Bellani, Cinzia Perlini, Adele Ferro, Stefania Cerruti, Gianluca Rambaldelli, Miriam Isola, Roberto Cerini, Nicola Dusi, Nicola Andreone, Matteo Balestrieri, Roberto Pozzi Mucelli, Michele Tansella, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review


Genetic, neuropathological and magnetic resonance imaging findings support the presence of diffuse white matter cytoarchitectural disruption in bipolar disorder. In this study, diffusion-weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 patients with DSM-IV bipolar disorder and 35 matched normal controls. DWI images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined over regions of interest placed, bilaterally, in the frontal, temporal, parietal, and occipital white matter. Significantly increased ADC values were found in bipolar patients with respect to normal controls in the right temporal lobe, left parietal lobe and bilateral occipital lobes. ADC values did not associate significantly with age or with clinical variables (p>0.05). Diffuse cortical white matter alterations on DWI in bipolar disorder denote widespread disruption of white matter integrity and may be due to altered myelination and/or axonal integrity.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalFunctional Neurology
Issue number1
Publication statusPublished - Jan 2012


  • Cortical white matter
  • Diffusion-weighted imaging
  • Magnetic resonance
  • Mood disorders
  • Neuroimaging
  • Neuroscience

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'White matter microstructure alterations in bipolar disorder'. Together they form a unique fingerprint.

Cite this