White matter microstructure and apathy level in amnestic mild cognitive impairment

Claudia Cacciari, Marta Moraschi, Margherita Di Paola, Andrea Cherubini, Maria Donata Orfei, Federico Giove, Bruno Maraviglia, Carlo Caltagirone, Gianfranco Spalletta

Research output: Contribution to journalArticlepeer-review


In this study, we assess white matter microstructural deficit correlates of apathy level in 20 patients with amnestic mild cognitive impairment by means of diffusion tensor imaging. Mean diffusivity correlated positively with apathy level in the right temporal portion of the uncinate, middle longitudinal and inferior longitudinal fasciculi and in the parathalamic white matter, the fornix and the posterior cingulum of the right hemisphere. Fractional anisotropy results confirmed evidence of disconnection associated with apathy in all white matter areas except the middle longitudinal fasciculus. These results support the view that alterations in the neural mechanisms underlying apathy level occur in the early phase of degenerative dementias.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalJournal of Alzheimer's Disease
Issue number2
Publication statusPublished - 2010


  • Apathy
  • diffusion tensor imaging
  • microstructure
  • mild cognitive impairment
  • MRI
  • white matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


Dive into the research topics of 'White matter microstructure and apathy level in amnestic mild cognitive impairment'. Together they form a unique fingerprint.

Cite this