Abstract
BACKGROUND AND PURPOSE: With respect to healthy controls (HCs), increased iron concentrations in the deep gray matter (GM) and decreased white matter (WM) integrity are common findings in multiple sclerosis (MS) patients. The association between these features of the disease remains poorly understood. We investigated the relationship between deep iron deposition in the deep GM and WM injury in associated fiber tracts in MS patients. METHODS: Sixty-six MS patients (mean age 50.0 years, median Expanded Disability Status Scale 5.25, mean disease duration 19.1 years) and 29 HCs, group matched for age and sex were imaged on a 1.5T scanner. Susceptibility-weighted imaging and diffusion tensor imaging (DTI) were used for assessing high-pass filtered phase values in the deep GM and normal appearing WM (NAWM) integrity in associated fiber tracts, respectively. Correlation analyses investigated the associations between filtered phase values (suggestive of iron content) and WM damage. RESULTS: Areas indicative of increased iron levels were found in the left and right caudates as well as in the left thalamus. MS patients presented with decreased DTI-derived measures of tissue integrity in the associated WM tracts. Greater mean, axial and radial diffusivities were associated with increased iron levels in all three GM areas (r values .393 to .514 with corresponding P values .003 to
| Original language | English |
|---|---|
| Journal | Journal of Neuroimaging |
| DOIs | |
| Publication status | E-pub ahead of print - May 30 2016 |
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Keywords
- Diffusion tensor imaging
- Iron deposition
- MRI
- Multiple sclerosis
- Tractography
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
Cite this
White Matter Tract Injury is Associated with Deep Gray Matter Iron Deposition in Multiple Sclerosis. / Bergsland, Niels; Tavazzi, Eleonora; Laganà, Maria Marcella; Baglio, Francesca; Cecconi, Pietro; Viotti, Stefano; Zivadinov, Robert; Baselli, Giuseppe; Rovaris, Marco.
In: Journal of Neuroimaging, 30.05.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - White Matter Tract Injury is Associated with Deep Gray Matter Iron Deposition in Multiple Sclerosis
AU - Bergsland, Niels
AU - Tavazzi, Eleonora
AU - Laganà, Maria Marcella
AU - Baglio, Francesca
AU - Cecconi, Pietro
AU - Viotti, Stefano
AU - Zivadinov, Robert
AU - Baselli, Giuseppe
AU - Rovaris, Marco
PY - 2016/5/30
Y1 - 2016/5/30
N2 - BACKGROUND AND PURPOSE: With respect to healthy controls (HCs), increased iron concentrations in the deep gray matter (GM) and decreased white matter (WM) integrity are common findings in multiple sclerosis (MS) patients. The association between these features of the disease remains poorly understood. We investigated the relationship between deep iron deposition in the deep GM and WM injury in associated fiber tracts in MS patients. METHODS: Sixty-six MS patients (mean age 50.0 years, median Expanded Disability Status Scale 5.25, mean disease duration 19.1 years) and 29 HCs, group matched for age and sex were imaged on a 1.5T scanner. Susceptibility-weighted imaging and diffusion tensor imaging (DTI) were used for assessing high-pass filtered phase values in the deep GM and normal appearing WM (NAWM) integrity in associated fiber tracts, respectively. Correlation analyses investigated the associations between filtered phase values (suggestive of iron content) and WM damage. RESULTS: Areas indicative of increased iron levels were found in the left and right caudates as well as in the left thalamus. MS patients presented with decreased DTI-derived measures of tissue integrity in the associated WM tracts. Greater mean, axial and radial diffusivities were associated with increased iron levels in all three GM areas (r values .393 to .514 with corresponding P values .003 to
AB - BACKGROUND AND PURPOSE: With respect to healthy controls (HCs), increased iron concentrations in the deep gray matter (GM) and decreased white matter (WM) integrity are common findings in multiple sclerosis (MS) patients. The association between these features of the disease remains poorly understood. We investigated the relationship between deep iron deposition in the deep GM and WM injury in associated fiber tracts in MS patients. METHODS: Sixty-six MS patients (mean age 50.0 years, median Expanded Disability Status Scale 5.25, mean disease duration 19.1 years) and 29 HCs, group matched for age and sex were imaged on a 1.5T scanner. Susceptibility-weighted imaging and diffusion tensor imaging (DTI) were used for assessing high-pass filtered phase values in the deep GM and normal appearing WM (NAWM) integrity in associated fiber tracts, respectively. Correlation analyses investigated the associations between filtered phase values (suggestive of iron content) and WM damage. RESULTS: Areas indicative of increased iron levels were found in the left and right caudates as well as in the left thalamus. MS patients presented with decreased DTI-derived measures of tissue integrity in the associated WM tracts. Greater mean, axial and radial diffusivities were associated with increased iron levels in all three GM areas (r values .393 to .514 with corresponding P values .003 to
KW - Diffusion tensor imaging
KW - Iron deposition
KW - MRI
KW - Multiple sclerosis
KW - Tractography
UR - http://www.scopus.com/inward/record.url?scp=84971372223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971372223&partnerID=8YFLogxK
U2 - 10.1111/jon.12364
DO - 10.1111/jon.12364
M3 - Article
AN - SCOPUS:84971372223
JO - Journal of Neuroimaging
JF - Journal of Neuroimaging
SN - 1051-2284
ER -