Abstract
Do cerebrovascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI) as a putative preclinical stage of AD? Here we tested the hypothesis that directionality of fronto-parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white-matter vascular load was quantified based on magnetic resonance images (0-30 visual rating scale). EEG rhythms of interest were δ (2-4 Hz), θ (4-8 Hz), α1 (8-10.5 Hz), α2 (10.5-13 Hz), β1 (13-20 Hz), and β2 (20-30 Hz). Directionality of fronto-parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto-parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at θ, α1, α2, and β1 in MCI V1 (high vascular load; N 5 42; MMSE = 26) than in MCI V- group (low vascular load; N = 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions.
Original language | English |
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Pages (from-to) | 1355-1367 |
Number of pages | 13 |
Journal | Human Brain Mapping |
Volume | 29 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- Alzheimer's disease
- Electroencephalography
- Magnetic resonance imaging
- Mild cognitive impairment
- Walhund scale
- White-matter vascular lesion
ASJC Scopus subject areas
- Clinical Neurology
- Anatomy
- Neurology
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology