White matter vascular lesions are related to parietal-to-frontal coupling of EEG rhythms in mild cognitive impairment

Claudio Babiloni, Giovanni B. Frisoni, Michela Pievani, Fabrizio Vecchio, Francesco Infarinato, Cristina Geroldi, Serenella Salinari, Raffaele Ferri, Claudia Fracassi, Fabrizio Eusebi, Paolo M. Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

Do cerebrovascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI) as a putative preclinical stage of AD? Here we tested the hypothesis that directionality of fronto-parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white-matter vascular load was quantified based on magnetic resonance images (0-30 visual rating scale). EEG rhythms of interest were δ (2-4 Hz), θ (4-8 Hz), α1 (8-10.5 Hz), α2 (10.5-13 Hz), β1 (13-20 Hz), and β2 (20-30 Hz). Directionality of fronto-parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto-parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at θ, α1, α2, and β1 in MCI V1 (high vascular load; N 5 42; MMSE = 26) than in MCI V- group (low vascular load; N = 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions.

Original languageEnglish
Pages (from-to)1355-1367
Number of pages13
JournalHuman Brain Mapping
Volume29
Issue number12
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Alzheimer's disease
  • Electroencephalography
  • Magnetic resonance imaging
  • Mild cognitive impairment
  • Walhund scale
  • White-matter vascular lesion

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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