Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother

M. G. Paggi, A. Giordano

Research output: Contribution to journalArticle

Abstract

This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purpose is to critically analyze present evidence whether Rb2/p130 shares the role of a tumor suppressor. Taking into account the well-proven growth suppressive properties of Rb2/p130 and p107, we discuss the analysis of mutated or deleted forms of Rb2/p130 found in a number of human cancers. Finally, we take into consideration the data provided by the targeted disruption of each RB family gene, alone or in combination, in the mouse model.

Original languageEnglish
Pages (from-to)4651-4654
Number of pages4
JournalCancer Research
Volume61
Issue number12
Publication statusPublished - Jun 15 2001

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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