Abstract
Patients with a number of peripheral CD34+ cells ≤20/μL have recently been defined in the literature as "poor mobilizers". We retrospectively reviewed medical records from a total of 248 patients affected by hematological malignancies or solid tumors undergoing peripheral blood stem cell collection following chemotherapy plus G-CSF. On the basis of the CD34+ cell peak in peripheral blood following mobilization therapy, patients were defined as good mobilizers (group A, CD34+ cells ≥20/μL), relative poor mobilizers (group B, CD34+ cells 6 CD34+cells/kg for each transplantation procedure. All patients in group A, 20 patients in group B (57%) and 1 patient in group C (2.7%) were able to collect ≥2.0×10 6 CD34+cells/kg. The multivariate analysis confirmed that more than three lines of previous chemotherapy and a previous autologous PBSC transplantation negatively affect mobilization of CD34+ cells in peripheral blood. Our data suggest that a number of CD34+ cells ≤20/μL does not always result in a failed stem cell collection and in fact in our patient series more than 70% of the patients defined as poor mobilizers have indeed collected the minimum number of 2.0×10 6 CD34+cells/kg required for a successful transplantation. The use of new agent such as CXCR4 antagonist plerixafor might further improve mobilization efficacy in such patients.
| Original language | English |
|---|---|
| Pages (from-to) | 27-32 |
| Number of pages | 6 |
| Journal | Transfusion and Apheresis Science |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 2012 |
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Keywords
- CD34+ cells
- Poor mobilizers
- Stem cell mobilization
ASJC Scopus subject areas
- Hematology
Cite this
Who should be really considered as a poor mobilizer in the plerixafor era? / Andreola, Giovanna; Vanazzi, Anna; Radice, Davide; Babic, Aleksandra; Rabascio, Cristina; Negri, Mara; Martinelli, Giovanni; Laszlo, Daniele.
In: Transfusion and Apheresis Science, Vol. 47, No. 1, 08.2012, p. 27-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Who should be really considered as a poor mobilizer in the plerixafor era?
AU - Andreola, Giovanna
AU - Vanazzi, Anna
AU - Radice, Davide
AU - Babic, Aleksandra
AU - Rabascio, Cristina
AU - Negri, Mara
AU - Martinelli, Giovanni
AU - Laszlo, Daniele
PY - 2012/8
Y1 - 2012/8
N2 - Patients with a number of peripheral CD34+ cells ≤20/μL have recently been defined in the literature as "poor mobilizers". We retrospectively reviewed medical records from a total of 248 patients affected by hematological malignancies or solid tumors undergoing peripheral blood stem cell collection following chemotherapy plus G-CSF. On the basis of the CD34+ cell peak in peripheral blood following mobilization therapy, patients were defined as good mobilizers (group A, CD34+ cells ≥20/μL), relative poor mobilizers (group B, CD34+ cells 6 CD34+cells/kg for each transplantation procedure. All patients in group A, 20 patients in group B (57%) and 1 patient in group C (2.7%) were able to collect ≥2.0×10 6 CD34+cells/kg. The multivariate analysis confirmed that more than three lines of previous chemotherapy and a previous autologous PBSC transplantation negatively affect mobilization of CD34+ cells in peripheral blood. Our data suggest that a number of CD34+ cells ≤20/μL does not always result in a failed stem cell collection and in fact in our patient series more than 70% of the patients defined as poor mobilizers have indeed collected the minimum number of 2.0×10 6 CD34+cells/kg required for a successful transplantation. The use of new agent such as CXCR4 antagonist plerixafor might further improve mobilization efficacy in such patients.
AB - Patients with a number of peripheral CD34+ cells ≤20/μL have recently been defined in the literature as "poor mobilizers". We retrospectively reviewed medical records from a total of 248 patients affected by hematological malignancies or solid tumors undergoing peripheral blood stem cell collection following chemotherapy plus G-CSF. On the basis of the CD34+ cell peak in peripheral blood following mobilization therapy, patients were defined as good mobilizers (group A, CD34+ cells ≥20/μL), relative poor mobilizers (group B, CD34+ cells 6 CD34+cells/kg for each transplantation procedure. All patients in group A, 20 patients in group B (57%) and 1 patient in group C (2.7%) were able to collect ≥2.0×10 6 CD34+cells/kg. The multivariate analysis confirmed that more than three lines of previous chemotherapy and a previous autologous PBSC transplantation negatively affect mobilization of CD34+ cells in peripheral blood. Our data suggest that a number of CD34+ cells ≤20/μL does not always result in a failed stem cell collection and in fact in our patient series more than 70% of the patients defined as poor mobilizers have indeed collected the minimum number of 2.0×10 6 CD34+cells/kg required for a successful transplantation. The use of new agent such as CXCR4 antagonist plerixafor might further improve mobilization efficacy in such patients.
KW - CD34+ cells
KW - Poor mobilizers
KW - Stem cell mobilization
UR - http://www.scopus.com/inward/record.url?scp=84862883674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862883674&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2012.03.004
DO - 10.1016/j.transci.2012.03.004
M3 - Article
VL - 47
SP - 27
EP - 32
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
SN - 1473-0502
IS - 1
ER -