WHO strategies for the programmatic management of drug-resistant tuberculosis

Alberto Matteelli, Rosella Centis, Lia D’Ambrosio, Giovanni Sotgiu, Marina Tadolini, Emanuele Pontali, Antonio Spanevello, Giovanni Battista Migliori

Research output: Contribution to journalReview articlepeer-review


Introduction: Adequate management of drug-resistant tuberculosis (TB), including multidrug- (MDR) and extensively drug-resistant (XDR-) TB are within the priorities of the newly launched World Health Organization's End TB and Elimination Strategies. Areas covered: This manuscript presents the evidence on the MDR- /XDR-TB epidemiology and discusses how the five recommended priority actions can be applied at the programmatic level to tackle the epidemic: 1) prevent development of MDR-TB thorough high quality treatment of drug- susceptible TB; 2) expand rapid testing and detection of drug-resistant TB; 3) provide immediate access to effective treatment and proper care; 4) prevent transmission through infection control; 5) increase political commitment and financing. A non-systematic review using Pubmed was carried out in addition to additional relevant information taken from the abstracts of international scientific conferences. Expert commentary: Current and future control of MDR-TB significantly relies on the correct use of new diagnostics and new drugs from one side, and on the consistent application of the five core interventions at the programmatic level. In addition, it is mandatory to tackle the social determinants and socio-economic barriers favouring the MDR-TB, otherwise it will not be possible to reach the planned goals as well as TB Elimination.

Original languageEnglish
Pages (from-to)991-1002
Number of pages12
JournalExpert Review of Respiratory Medicine
Issue number9
Publication statusPublished - Sep 1 2016


  • Drug-resistant TB
  • elimination
  • End TB Strategy
  • new drugs
  • prevention
  • TB control
  • XDR-TB

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health


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