WHO/EORTC classification of cutaneous lymphomas 2005: Histological and molecular aspects

Günter Burg, Werner Kempf, Antonio Cozzio, Josef Feit, Rein Willemze, Elaine S. Jaffe, Reinhard Dummer, Emilio Berti, Lorenzo Cerroni, Sergio Chimenti, José L. Diaz-Perez, Florent Grange, Nancy L. Harris, Dmitry V. Kazakov, Helmut Kerl, Michael Kurrer, Robert Knobler, Chris J L M Meijer, Nicola Pimpinelli, Elisabeth RalfkiaerRobin Russell-Jones, Christian Sander, Marco Santucci, Wolfram Sterry, Steven H. Swerdlow, Maarten H. Vermeer, Janine Wechsler, Sean Whittaker

Research output: Contribution to journalArticle

Abstract

The new WHO/EORTC classification for cutaneous lymphomas comprises mature T-cell and natural killer (NK)-Cell neoplasms, mature B-cell neoplasms, and immature hematopoietic malignancies. It reflects the unique features of lymphoproliferative diseases of the skin, and at the same time it is as compatible as possible with the concepts underlying the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. This article reviews the histological, phenotypical, and molecular genetic features of the various nosological entities included in this new classification. These findings always have to be interpreted in the context of the clinical features and biologic behavior. Aim: To review the histological, phenotypical and molecular genetic features of the various nosological entities of the new WHO/EORTC classification for cutaneous lymphomas. Methods: Extensive review of the literature cited in Medline and own data of the authors. Results: The WHO/EORTC classification of cutaneous lymphomas comprises mature T-cell and NK-cell neoplasms, mature B-cell neoplasms and immature hematopoietic malignancies. It reflects the unique features of primary cutaneous lymphoproliferative diseases. Conclusion: This classification is as much as possible compatible with the concept of the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. The histological, phenotypical and molecular genetic features always have to be interpreted in the context of the clinical features and biologic behavior.

Original languageEnglish
Pages (from-to)647-674
Number of pages28
JournalJournal of Cutaneous Pathology
Volume32
Issue number10
DOIs
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

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    Burg, G., Kempf, W., Cozzio, A., Feit, J., Willemze, R., Jaffe, E. S., Dummer, R., Berti, E., Cerroni, L., Chimenti, S., Diaz-Perez, J. L., Grange, F., Harris, N. L., Kazakov, D. V., Kerl, H., Kurrer, M., Knobler, R., Meijer, C. J. L. M., Pimpinelli, N., ... Whittaker, S. (2005). WHO/EORTC classification of cutaneous lymphomas 2005: Histological and molecular aspects. Journal of Cutaneous Pathology, 32(10), 647-674. https://doi.org/10.1111/j.0303-6987.2005.00495.x