Whole-abdomen radiation in patients with advanced ovarian carcinoma after surgery, chemotherapy and second-look laparotomy

R. Greiner, A. Goldhirsch, B. W. Davis, E. Dreher, T. Peyer, G. Locher, H. Neuenschwander, R. Joss, K. Brunner, P. Veraguth

Research output: Contribution to journalArticlepeer-review

Abstract

Forthy-three patients with ovarian carcinoma were treated with whole-abdomen radiation (moving strip±pelvic radiation), 15 patients had not received prior chemotherapy, and 28 patients were irradiated following chemotherapy and second-look laparotomy. Ten of these had been treated with a variety of chemotherapy regimens (L-PAM, CHAD, Hexa-CAF). Eighteen patients were treated in an ongoing prospective trial with combination chemotherapy consisting of melphalan, cis-platinum, and hexamethylmelamin (HexaPAMP). Thrombocytopenia was the limiting toxicity. A temporary pause in the radiation schedule allowing platelets to recover made it possible to complete treatment in 80% of the patients. The acute toxic effects, which included the expected side effects of radiation therapy on intestine, liver and lung, were not more frequent or more severe in the patients who had received prior chemotherapy than in those who had radiation therapy alone. Thirty-four of 43 patients (stage I, seven patients; stage II, seven patients; stage III, 27 patients; stage IV, two patients) are alive and without evidence of disease 26+ months (range 7 to 64 months) after entering the postsurgical treatment program.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalJournal of Cancer Research and Clinical Oncology
Volume107
Issue number2
DOIs
Publication statusPublished - Apr 1984

Keywords

  • Chemotherapy
  • Ovarian carcinoma
  • Second-look laparotomy
  • Whole-abdomen radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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