TY - JOUR
T1 - Whole blood fatty acid composition at birth
T2 - From the maternal compartment to the infant
AU - Agostoni, Carlo
AU - Galli, Claudio
AU - Riva, Enrica
AU - Risé, Patrizia
AU - Colombo, Claudio
AU - Giovannini, Marcello
AU - Marangoni, Franca
PY - 2011/8
Y1 - 2011/8
N2 - Background & aims: The biological role of fatty acids (FA) in the perinatal period is under active investigation. We here describe the application of a simplified microanalytical procedure to compare the FA profile of maternal, umbilical cord and infant whole blood, inclusive of all circulating lipid fractions and cells. Methods: The FA composition has been analyzed with a micromethod in 16 triplets, including maternal blood, cord blood at delivery and infant blood at day 4, respectively. Results: As expected, the FA composition of blood samples withdrawn from the umbilical cord is more similar to the FA composition of blood from 4-day old infants than the FA pattern of maternal blood at delivery. Nevertheless, infant blood FA profile differed from cord for lower long-chain polyunsaturated FA and higher monounsaturated FA. Conclusions: Our explorative data using whole blood microanalysis confirm the progressive increase of long-chain polyunsaturated FA levels from the mothers towards cord and then infant blood.
AB - Background & aims: The biological role of fatty acids (FA) in the perinatal period is under active investigation. We here describe the application of a simplified microanalytical procedure to compare the FA profile of maternal, umbilical cord and infant whole blood, inclusive of all circulating lipid fractions and cells. Methods: The FA composition has been analyzed with a micromethod in 16 triplets, including maternal blood, cord blood at delivery and infant blood at day 4, respectively. Results: As expected, the FA composition of blood samples withdrawn from the umbilical cord is more similar to the FA composition of blood from 4-day old infants than the FA pattern of maternal blood at delivery. Nevertheless, infant blood FA profile differed from cord for lower long-chain polyunsaturated FA and higher monounsaturated FA. Conclusions: Our explorative data using whole blood microanalysis confirm the progressive increase of long-chain polyunsaturated FA levels from the mothers towards cord and then infant blood.
KW - Cord blood
KW - Fatty acids
KW - Long-chain polyunsaturated fatty acids
KW - Newborn infants
KW - Pregnancy
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U2 - 10.1016/j.clnu.2011.01.016
DO - 10.1016/j.clnu.2011.01.016
M3 - Article
C2 - 21388724
AN - SCOPUS:79960699794
VL - 30
SP - 503
EP - 505
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 4
ER -