Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

Alfonso Bellia, Bruno Ruscello, Rolando Bolognino, Gianluca Briotti, Paolo Roberto Gabrielli, Adriano Silvestri, Cristina Rosazza, Francesca Ambruoso, Mauro Lombardo, Andrea Bernardini, Cosimo Calabrese, Davide Lauro, Stefano D'Ottavio

Research output: Contribution to journalArticlepeer-review


We investigated early effects of Whole-Body Electromyostimulation added to hypocaloric diet on metabolic syndrome features in sedentary middle-aged individuals. We randomly assigned 25 patients to Whole-Body Electromyostimulation plus caloric restriction or caloric restriction alone for 26 weeks. Anthropometrics, blood pressure, fasting glucose and insulin, HOMA-IR, glycated hemoglobin, lipids, uric acid, creatinphosphokynase, C-reactive protein were assessed. Body composition was evaluated with direct-segmental, multi-frequency Bioelectrical Impedance Analysis. Both groups lost approximately 10% of weight, with similar effects on waist circumference and fat mass. Change in free-fat mass was significantly different between groups (caloric restriction -1.5±0.2 vs. Whole-Body Electromyostimulation plus caloric restriction +1.1±0.4 kg, p=0.03). Whole-Body Electromyostimulation plus caloric restriction group experienced greater percent reductions in insulin (-45.5±4.4 vs. -28.2±3.6%, p=0.002), HOMA-IR (-51.3±3.2 vs. -25.1±1.8%, p=0.001), triglycerides (-22.5±2.9 vs. -4.1±1.6%, p=0.004) and triglycerides/HDL (p=0.028). Subjects trained with Whole-Body Electromyostimulation had also significant improvement in systolic pressure (138±4 vs. 126±7 mmHg, p=0.038). No discontinuations for adverse events occurred. In middle-aged sedentary subjects with the metabolic syndrome, Whole-Body Electromyostimulation with caloric restriction for 26 weeks can improve insulin-resistance and lipid profile compared to diet alone. Further studies are needed to ascertain long-term efficacy and feasibility of this approach in individuals with the metabolic syndrome.

Original languageEnglish
Pages (from-to)751-758
Number of pages8
JournalInternational Journal of Sports Medicine
Issue number11
Publication statusPublished - Oct 1 2020


  • cardiovascular risk
  • insulin-resistance
  • metabolic syndrome
  • overweight
  • resistance training
  • whole-body electromyostimulation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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