Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

Massimo Galia, Domenico Albano, Corrado Tarella, Caterina Patti, Luca Maria Sconfienza, Antonino Mulè, Pierpaolo Alongi, Massimo Midiri, Roberto Lagalla

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

ᅟ: The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by ‘indolent’ clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and CT. A major concern is radiation exposure due to regularly monitoring by conventional imaging procedures. Several studies have demonstrated the reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging. WB-MRI could be useful for active surveillance in i-NHLs providing the suspect of disease progression that can be then confirmed by additional diagnostic procedures, including 18F-FDG-PET/CT. The directive 2013/59 by the European Union claims that if a radiation-free imaging technique allows obtaining the same diagnostic results, it should be invariably used. In this setting, WB-MRI may be considered a reasonable option in i-NHLs under WW, replacing imaging modalities that cause exposure to ionising radiations. This will help to reduce the cancer risk in i-NHL patients for whom chemo-/radiotherapy remain the usual treatment options following the usually long WW phase. The scientific community should raise the awareness of the risk of ionising radiations in i-NHLs and the emphasise the need for establishing the proper place of WB-MRI in lymphoma imaging. Key Points: • Watchful waiting is a reasonable option in patients with indolent non-Hodgkin lymphomas. • Imaging is crucial to monitor patients with indolent non-Hodgkin lymphomas. • CT and18F-FDG-PET/CT are commonly used, implying a substantial radiation exposure. • WB-MRI is highly reliable in lymphoma staging. • WB-MRI may be considered to monitor indolent non-Hodgkin lymphomas under watchful waiting.

Original languageEnglish
Pages (from-to)1187-1193
Number of pages7
JournalEuropean Radiology
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2018

Fingerprint

Watchful Waiting
Non-Hodgkin's Lymphoma
Lymphoma
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Fluorodeoxyglucose F18
Ionizing Radiation
European Union
Natural History
Disease Progression
Radiotherapy
Radiation

Keywords

  • Ionising radiation
  • Lymphoma
  • Magnetic resonance imaging
  • Watchful waiting
  • Whole body imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Whole body magnetic resonance in indolent lymphomas under watchful waiting : The time is now. / Galia, Massimo; Albano, Domenico; Tarella, Corrado; Patti, Caterina; Sconfienza, Luca Maria; Mulè, Antonino; Alongi, Pierpaolo; Midiri, Massimo; Lagalla, Roberto.

In: European Radiology, Vol. 28, No. 3, 03.2018, p. 1187-1193.

Research output: Contribution to journalArticle

Galia, Massimo ; Albano, Domenico ; Tarella, Corrado ; Patti, Caterina ; Sconfienza, Luca Maria ; Mulè, Antonino ; Alongi, Pierpaolo ; Midiri, Massimo ; Lagalla, Roberto. / Whole body magnetic resonance in indolent lymphomas under watchful waiting : The time is now. In: European Radiology. 2018 ; Vol. 28, No. 3. pp. 1187-1193.
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