Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 96-106 |
| Number of pages | 11 |
| Journal | Pers. Ment. Health |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- adult
- borderline state
- brain cortex
- diagnostic imaging
- diffusion tensor imaging
- female
- human
- male
- middle aged
- nerve tract
- pathology
- white matter
- Adult
- Borderline Personality Disorder
- Cerebral Cortex
- Diffusion Tensor Imaging
- Female
- Humans
- Male
- Middle Aged
- Neural Pathways
- White Matter
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Whole-brain microstructural white matter alterations in borderline personality disorder patients : Personality and Mental Health. / Quattrini, G.; Marizzoni, M.; Magni, L.R. et al.
In: Pers. Ment. Health, Vol. 13, No. 2, 2019, p. 96-106.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Whole-brain microstructural white matter alterations in borderline personality disorder patients
T2 - Personality and Mental Health
AU - Quattrini, G.
AU - Marizzoni, M.
AU - Magni, L.R.
AU - Magnaldi, S.
AU - Lanfredi, M.
AU - Rossi, G.
AU - Frisoni, G.B.
AU - Pievani, M.
AU - Rossi, R.
N1 - Cited By :1 Export Date: 10 February 2020 Correspondence Address: Rossi, G.; Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliItaly; email: rrossi@fatebenefratelli.eu Funding details: GR-2011-02351347 Funding text 1: This work was supported by the Italian Ministry of Health (“ricerca corrente” and GR-2011-02351347) and 5× 1000 funds. 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PY - 2019
Y1 - 2019
N2 - Background: Borderline personality disorder (BPD) is a psychiatric condition associated with the impairment of the frontolimbic network. However, a growing body of studies suggests that brain dysfunction underling BPD could involve other brain areas. We explored the whole-brain white matter (WM) organization in BPD patients to clarify the structural pattern underlying the disease and its relationship with clinical features. Methods: Fourteen BPD patients and 14 healthy controls underwent a multidimensional clinical assessment and diffusion tensor imaging acquisition. Measures of fractional anisotropy (FA) and mean, axial and radial (RD) diffusivity were collected, and alterations in the WM were assessed using the voxelwise approach, including substance and alcohol abuse as covariates. Voxelwise regression analysis was performed to identify associations between microstructural changes and clinical feature in BPD. Results: Group comparisons showed alterations only for FA and RD: FA decreased in the right posterior hemisphere, while RD increased bilaterally and widespread in anterior and posterior areas (p
AB - Background: Borderline personality disorder (BPD) is a psychiatric condition associated with the impairment of the frontolimbic network. However, a growing body of studies suggests that brain dysfunction underling BPD could involve other brain areas. We explored the whole-brain white matter (WM) organization in BPD patients to clarify the structural pattern underlying the disease and its relationship with clinical features. Methods: Fourteen BPD patients and 14 healthy controls underwent a multidimensional clinical assessment and diffusion tensor imaging acquisition. Measures of fractional anisotropy (FA) and mean, axial and radial (RD) diffusivity were collected, and alterations in the WM were assessed using the voxelwise approach, including substance and alcohol abuse as covariates. Voxelwise regression analysis was performed to identify associations between microstructural changes and clinical feature in BPD. Results: Group comparisons showed alterations only for FA and RD: FA decreased in the right posterior hemisphere, while RD increased bilaterally and widespread in anterior and posterior areas (p
KW - adult
KW - borderline state
KW - brain cortex
KW - diagnostic imaging
KW - diffusion tensor imaging
KW - female
KW - human
KW - male
KW - middle aged
KW - nerve tract
KW - pathology
KW - white matter
KW - Adult
KW - Borderline Personality Disorder
KW - Cerebral Cortex
KW - Diffusion Tensor Imaging
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Neural Pathways
KW - White Matter
U2 - 10.1002/pmh.1441
DO - 10.1002/pmh.1441
M3 - Article
VL - 13
SP - 96
EP - 106
JO - Pers. Ment. Health
JF - Pers. Ment. Health
SN - 1932-8621
IS - 2
ER -