Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 96-106 |
| Number of pages | 11 |
| Journal | Pers. Ment. Health |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- adult
- borderline state
- brain cortex
- diagnostic imaging
- diffusion tensor imaging
- female
- human
- male
- middle aged
- nerve tract
- pathology
- white matter
- Adult
- Borderline Personality Disorder
- Cerebral Cortex
- Diffusion Tensor Imaging
- Female
- Humans
- Male
- Middle Aged
- Neural Pathways
- White Matter
Fingerprint Dive into the research topics of 'Whole-brain microstructural white matter alterations in borderline personality disorder patients: Personality and Mental Health'. Together they form a unique fingerprint.
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Whole-brain microstructural white matter alterations in borderline personality disorder patients : Personality and Mental Health. / Quattrini, G.; Marizzoni, M.; Magni, L.R.; Magnaldi, S.; Lanfredi, M.; Rossi, G.; Frisoni, G.B.; Pievani, M.; Rossi, R.
In: Pers. Ment. Health, Vol. 13, No. 2, 2019, p. 96-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Whole-brain microstructural white matter alterations in borderline personality disorder patients
T2 - Personality and Mental Health
AU - Quattrini, G.
AU - Marizzoni, M.
AU - Magni, L.R.
AU - Magnaldi, S.
AU - Lanfredi, M.
AU - Rossi, G.
AU - Frisoni, G.B.
AU - Pievani, M.
AU - Rossi, R.
N1 - Cited By :1 Export Date: 10 February 2020 Correspondence Address: Rossi, G.; Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliItaly; email: rrossi@fatebenefratelli.eu Funding details: GR-2011-02351347 Funding text 1: This work was supported by the Italian Ministry of Health (“ricerca corrente” and GR-2011-02351347) and 5× 1000 funds. References: (2013) Diagnostic and Statistical Manual of Mental Disorders: DSM-5, , 5th, Edition., Washington, D.C., American Psychiatric Association; Skodol, A.E., Gunderson, J.G., Pfohl, B., Widiger, T.A., Livesley, W.J., Siever, L.J., The borderline diagnosis I: psychopathology, comorbidity, and personality structure (2002) Biol Psychiatry, 51 (12), pp. 936-950; Lieb, K., Zanarini, M.C., Schmahl, C., Linehan, M.M., Bohus, M., Borderline personality disorder (2004) Lancet, 364 (9432), pp. 453-461; Silbersweig, D., Clarkin, J.F., Goldstein, M., Kernberg, O.F., Tuescher, O., Levy, K.N., Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder (2007) Am J Psychiatry, 164 (12), pp. 1832-1841; Leichsenring, F., Leibing, E., Kruse, J., New, A.S., Leweke, F., Borderline personality disorder (2011) Lancet, 377 (9759), pp. 74-84; Catani, M., Dell'acqua, F., Thiebaut de Schotten, M., A revised limbic system model for memory, emotion and behaviour (2013) Neurosci Biobehav Rev, 37 (8), pp. 1724-1737; Le Bihan, D., Diffusion MRI: what water tells us about the brain (2014) EMBO Mol Med, 6 (5), pp. 569-573; Pierpaoli, C., Basser, P.J., Toward a quantitative assessment of diffusion anisotropy (1996) Magn Reson Med, 36 (6), pp. 893-906; Kubicki, M., Park, H., Westin, C.F., Nestor, P.G., Mulkern, R.V., Maier, S.E., DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity (2005) Neuroimage, 26 (4), pp. 1109-1118; Bellani, M., Brambilla, P., Diffusion imaging studies of white matter integrity in bipolar disorder (2011) Epidemiol Psychiatr Sci, 20 (2), pp. 137-140; Harsan, L.A., Poulet, P., Guignard, B., Steibel, J., Parizel, N., de Sousa, P.L., Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging (2006) J Neurosci Res, 83 (3), pp. 392-402; Song, S.K., Sun, S.W., Ramsbottom, M.J., Chang, C., Russell, J., Cross, A.H., Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water (2002) Neuroimage, 17 (3), pp. 1429-1436. , Nov; Grant, J.E., Correia, S., Brennan-Krohn, T., Malloy, P.F., Laidlaw, D.H., Schulz, S.C., Frontal white matter integrity in borderline personality disorder with self-injurious behavior (2007) J Neuropsychiatry Clin Neurosci, 19 (4), pp. 383-390. , Fall; Rusch, N., Weber, M., Il'yasov, K.A., Lieb, K., Ebert, D., Hennig, J., Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder (2007) Neuroimage, 35 (2), pp. 738-747; Rusch, N., Bracht, T., Kreher, B.W., Schnell, S., Glauche, V., Il'yasov, K.A., Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder (2010) Psychiatry Res, 181 (2), pp. 151-154; Carrasco, J.L., Tajima-Pozo, K., Diaz-Marsa, M., Casado, A., Lopez-Ibor, J.J., Arrazola, J., Microstructural white matter damage at orbitofrontal areas in borderline personality disorder (2012) J Affect Disord, 139 (2), pp. 149-153. , Jul; Gan, J., Yi, J., Zhong, M., Cao, X., Jin, X., Liu, W., Abnormal white matter structural connectivity in treatment-naive young adults with borderline personality disorder (2016) Acta Psychiatr Scand, 134 (6), pp. 494-503; Lischke, A., Domin, M., Freyberger, H.J., Grabe, H.J., Mentel, R., Bernheim, D., Structural alterations in the corpus callosum are associated with suicidal behavior in women with borderline personality disorder (2017) Front Hum Neurosci, 11, p. 196; Whalley, H.C., Nickson, T., Pope, M., Nicol, K., Romaniuk, L., Bastin, M.E., White matter integrity and its association with affective and interpersonal symptoms in borderline personality disorder (2015) Neuroimage Clin, 7, pp. 476-481; Ninomiya, T., Oshita, H., Kawano, Y., Goto, C., Matsuhashi, M., Masuda, K., Reduced white matter integrity in borderline personality disorder: a diffusion tensor imaging study (2018) J Affect Disord, 225, pp. 723-732; Salvador, R., Vega, D., Pascual, J.C., Marco, J., Canales-Rodriguez, E.J., Aguilar, S., Converging medial frontal resting state and diffusion-based abnormalities in borderline personality disorder (2016) Biol Psychiatry, 79 (2), pp. 107-116; First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W., Benjamin, L., (1994) Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), , New York, New York State Psychiatric Institute, Biometric Research Department; First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W., (1995) Structured Clinical Interview for DSM-IV Axis I Disorders—Patient Edition (SCID-I/P), , New York, New York State Psychiatric Institute, Biometric Research Department; Derogatis, L.R., Lipman, R.S., Covi, L., (1977) Administration, Scoring and Procedures Manual-I for the R (Revised) Version and Other Instruments of the Psychopathology Rating Scales Series, , Chicago, Johns Hopkins University School of Medicine; Gigantesco, A., Vittorielli, M., Pioli, R., Falloon, I.R., Rossi, G., Morosini, P., The VADO approach in psychiatric rehabilitation: a randomized controlled trial (2006) Psychiatr Serv, 57 (12), pp. 1778-1783; Bagby, R.M., Taylor, G.J., Parker, J.D., The twenty-item Toronto Alexithymia Scale-II. Convergent, discriminant, and concurrent validity (1994) J Psychosom Res, 38 (1), pp. 33-40; Patton, J.H., Stanford, M.S., Barratt, E.S., Factor structure of the Barratt Impulsiveness Scale (1995) J Clin Psychol, 51 (6), pp. 768-774. , Nov; Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., Jacobs, G.A., (1983) Manual for the State-Trait Anxiety Inventory, , Palo Alto, CA, Consulting Psychologists Press; Oguz, I., Farzinfar, M., Matsui, J., Budin, F., Liu, Z., Gerig, G., DTIPrep: quality control of diffusion-weighted images (2014) Front Neuroinform, 8, p. 4; Smith, S.M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T.E., Mackay, C.E., Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data (2006) Neuroimage, 31 (4), pp. 1487-1505; Mori, S., Oishi, K., Jiang, H., Jiang, L., Li, X., Akhter, K., Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template (2008) Neuroimage, 40 (2), pp. 570-582; Jovicich, J., Marizzoni, M., Bosch, B., Bartres-Faz, D., Arnold, J., Benninghoff, J., Multisite longitudinal reliability of tract-based spatial statistics in diffusion tensor imaging of healthy elderly subjects (2014) Neuroimage, 101, pp. 390-403. , Nov 1; Gunderson, J.G., Disturbed relationships as a phenotype for borderline personality disorder (2007) Am J Psychiatry, 164 (11), pp. 1637-1640; Jeung, H., Herpertz, S.C., Impairments of interpersonal functioning: empathy and intimacy in borderline personality disorder (2014) Psychopathology, 47 (4), pp. 220-234; Beeney, J.E., Hallquist, M.N., Ellison, W.D., Levy, K.N., Self-other disturbance in borderline personality disorder: neural, self-report, and performance-based evidence (2016) Personal Disord, 7 (1), pp. 28-39; Amft, M., Bzdok, D., Laird, A.R., Fox, P.T., Schilbach, L., Eickhoff, S.B., Definition and characterization of an extended social-affective default network (2015) Brain Struct Funct, 220 (2), pp. 1031-1049; Catani, M., Thiebaut de Schotten, M., A diffusion tensor imaging tractography atlas for virtual in vivo dissections (2008) Cortex, 44 (8), pp. 1105-1132; Li, C., Dang, C., Liu, G., Chen, L., Zhang, J., Li, J., Secondary damage in left-sided frontal white matter detected by diffusion tensor imaging is correlated with executive dysfunction in patients with acute infarction at the ipsilateral posterior corona radiata (2014) Eur J Med Res, 19, p. 44; Hagenhoff, M., Franzen, N., Koppe, G., Baer, N., Scheibel, N., Sammer, G., Executive functions in borderline personality disorder (2013) Psychiatry Res, 210 (1), pp. 224-231. , Nov 30; Baez, S., Marengo, J., Perez, A., Huepe, D., Font, F.G., Rial, V., Theory of mind and its relationship with executive functions and emotion recognition in borderline personality disorder (2015) J Neuropsychol, 9 (2), pp. 203-218. , Sep; Pollatos, O., Kirsch, W., Schandry, R., On the relationship between interoceptive awareness, emotional experience, and brain processes (2005) Brain Res Cogn Brain Res, 25 (3), pp. 948-962. , Dec; Frieling, H., Fischer, J., Wilhelm, J., Engelhorn, T., Bleich, S., Hillemacher, T., Microstructural abnormalities of the posterior thalamic radiation and the mediodorsal thalamic nuclei in females with anorexia nervosa—a voxel based diffusion tensor imaging (DTI) study (2012) J Psychiatr Res, 46 (9), pp. 1237-1242. , Sep; Bekrater-Bodmann, R., Chung, B.Y., Foell, J., Gescher, D.M., Bohus, M., Flor, H., Body plasticity in borderline personality disorder: a link to dissociation (2016) Compr Psychiatry, 69, pp. 36-44; Muller, L.E., Schulz, A., Andermann, M., Gabel, A., Gescher, D.M., Spohn, A., Cortical representation of afferent bodily signals in borderline personality disorder: neural correlates and relationship to emotional dysregulation (2015) JAMA Psychiat, 72 (11), pp. 1077-1086; Koenigsberg, H.W., Siever, L.J., Lee, H., Pizzarello, S., New, A.S., Goodman, M., Neural correlates of emotion processing in borderline personality disorder (2009) Psychiatry Res, 172 (3), pp. 192-199. , Jun 30; Lieberman, M.D., Gaunt, R., Gilbert, D.T., Trope, Y., Reflexion and reflection: a social cognitive neuroscience approach to attributional inference (2002) Adv Exp Soc Psychol, 34, pp. 199-249; Satpute, A.B., Lieberman, M.D., Integrating automatic and controlled processes into neurocognitive models of social cognition (2006) Brain Res, 1079 (1), pp. 86-97. , Mar 24; Nave, K.A., Myelination and support of axonal integrity by glia (2010) Nature, 468 (7321), pp. 244-252. , Nov 11; Barkovich, A.J., Deon, S., Hypomyelinating disorders: an MRI approach (2016) Neurobiol Dis, 87, pp. 50-58; Amad, A., Radua, J., Resting-state meta-analysis in borderline personality disorder: is the fronto-limbic hypothesis still valid? (2017) J Affect Disord, 212, pp. 7-9. , Apr 1; Visintin, E., De Panfilis, C., Amore, M., Balestrieri, M., Wolf, R.C., Sambataro, F., Mapping the brain correlates of borderline personality disorder: a functional neuroimaging meta-analysis of resting state studies (2016) J Affect Disord, 204, pp. 262-269. , Nov 1; Pierpaoli, C., Jezzard, P., Basser, P.J., Barnett, A., Di Chiro, G., Diffusion tensor MR imaging of the human brain (1996) Radiology, 201 (3), pp. 637-648. , Dec; Becker, M.P., Collins, P.F., Lim, K.O., Muetzel, R.L., Luciana, M., Longitudinal changes in white matter microstructure after heavy cannabis use (2015) Dev Cogn Neurosci, 16, pp. 23-35. , Dec; Fortier, C.B., Leritz, E.C., Salat, D.H., Lindemer, E., Maksimovskiy, A.L., Shepel, J., Widespread effects of alcohol on white matter microstructure (2014) Alcohol Clin Exp Res, 38 (12), pp. 2925-2933. , Dec; Szeszko, P.R., Robinson, D.G., Ikuta, T., Peters, B.D., Gallego, J.A., Kane, J., White matter changes associated with antipsychotic treatment in first-episode psychosis (2014) Neuropsychopharmacology, 39 (6), pp. 1324-1331. , May
PY - 2019
Y1 - 2019
N2 - Background: Borderline personality disorder (BPD) is a psychiatric condition associated with the impairment of the frontolimbic network. However, a growing body of studies suggests that brain dysfunction underling BPD could involve other brain areas. We explored the whole-brain white matter (WM) organization in BPD patients to clarify the structural pattern underlying the disease and its relationship with clinical features. Methods: Fourteen BPD patients and 14 healthy controls underwent a multidimensional clinical assessment and diffusion tensor imaging acquisition. Measures of fractional anisotropy (FA) and mean, axial and radial (RD) diffusivity were collected, and alterations in the WM were assessed using the voxelwise approach, including substance and alcohol abuse as covariates. Voxelwise regression analysis was performed to identify associations between microstructural changes and clinical feature in BPD. Results: Group comparisons showed alterations only for FA and RD: FA decreased in the right posterior hemisphere, while RD increased bilaterally and widespread in anterior and posterior areas (p
AB - Background: Borderline personality disorder (BPD) is a psychiatric condition associated with the impairment of the frontolimbic network. However, a growing body of studies suggests that brain dysfunction underling BPD could involve other brain areas. We explored the whole-brain white matter (WM) organization in BPD patients to clarify the structural pattern underlying the disease and its relationship with clinical features. Methods: Fourteen BPD patients and 14 healthy controls underwent a multidimensional clinical assessment and diffusion tensor imaging acquisition. Measures of fractional anisotropy (FA) and mean, axial and radial (RD) diffusivity were collected, and alterations in the WM were assessed using the voxelwise approach, including substance and alcohol abuse as covariates. Voxelwise regression analysis was performed to identify associations between microstructural changes and clinical feature in BPD. Results: Group comparisons showed alterations only for FA and RD: FA decreased in the right posterior hemisphere, while RD increased bilaterally and widespread in anterior and posterior areas (p
KW - adult
KW - borderline state
KW - brain cortex
KW - diagnostic imaging
KW - diffusion tensor imaging
KW - female
KW - human
KW - male
KW - middle aged
KW - nerve tract
KW - pathology
KW - white matter
KW - Adult
KW - Borderline Personality Disorder
KW - Cerebral Cortex
KW - Diffusion Tensor Imaging
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Neural Pathways
KW - White Matter
U2 - 10.1002/pmh.1441
DO - 10.1002/pmh.1441
M3 - Article
VL - 13
SP - 96
EP - 106
JO - Pers. Ment. Health
JF - Pers. Ment. Health
SN - 1932-8621
IS - 2
ER -