Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease

for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aims: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes. Methods: A total of 261 children with both T1DM and CD were enrolled. Serum lipid profiles at CD diagnosis were compared with those after 1 year of GFD and with those of 224 matched children with T1DM alone. The adherence to GFD was judged by means of CD-related antibodies. Results: At CD diagnosis, children with T1DM + CD showed higher LDL cholesterol (LDL-C) compared to children with T1DM alone. Gluten withdrawal failed to normalize LDL-C levels, not even in completely adherent individuals. HbA1c values were not influenced by GFD. The youngest children were characterized at diagnosis by lower levels of total cholesterol and on treatment by a greater decrease in triglycerides levels. Conclusions: An unfavorable lipid profile, characterized not only by low HDL-C levels but also by high LDL-C values, may increase the risk of cardiovascular disease in children with T1DM and untreated CD. Therefore, a strict gluten-free diet is mandatory in these children, especially the youngest.

Original languageEnglish
Pages (from-to)889-894
Number of pages6
JournalActa Diabetologica
Volume54
Issue number10
DOIs
Publication statusPublished - Oct 1 2017

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Celiac Disease
Type 1 Diabetes Mellitus
HDL Cholesterol
Gluten-Free Diet
Lipids
LDL Cholesterol
Glutens
Multicenter Studies
Triglycerides
Cardiovascular Diseases
Retrospective Studies
Cholesterol
Biopsy
Antibodies
Serum

Keywords

  • Celiac disease
  • Childhood-onset T1DM
  • Gluten-free diet
  • HbA1c
  • LDL cholesterol
  • Triglycerides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) (2017). Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease. Acta Diabetologica, 54(10), 889-894. https://doi.org/10.1007/s00592-017-1019-5

Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease. / for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

In: Acta Diabetologica, Vol. 54, No. 10, 01.10.2017, p. 889-894.

Research output: Contribution to journalArticle

for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) 2017, 'Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease', Acta Diabetologica, vol. 54, no. 10, pp. 889-894. https://doi.org/10.1007/s00592-017-1019-5
for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED). Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease. Acta Diabetologica. 2017 Oct 1;54(10):889-894. https://doi.org/10.1007/s00592-017-1019-5
for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED). / Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease. In: Acta Diabetologica. 2017 ; Vol. 54, No. 10. pp. 889-894.
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abstract = "Aims: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes. Methods: A total of 261 children with both T1DM and CD were enrolled. Serum lipid profiles at CD diagnosis were compared with those after 1 year of GFD and with those of 224 matched children with T1DM alone. The adherence to GFD was judged by means of CD-related antibodies. Results: At CD diagnosis, children with T1DM + CD showed higher LDL cholesterol (LDL-C) compared to children with T1DM alone. Gluten withdrawal failed to normalize LDL-C levels, not even in completely adherent individuals. HbA1c values were not influenced by GFD. The youngest children were characterized at diagnosis by lower levels of total cholesterol and on treatment by a greater decrease in triglycerides levels. Conclusions: An unfavorable lipid profile, characterized not only by low HDL-C levels but also by high LDL-C values, may increase the risk of cardiovascular disease in children with T1DM and untreated CD. Therefore, a strict gluten-free diet is mandatory in these children, especially the youngest.",
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T1 - Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease

AU - for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)

AU - Salardi, Silvana

AU - Maltoni, Giulio

AU - Zucchini, Stefano

AU - Iafusco, Dario

AU - Zanfardino, Angela

AU - Confetto, Santino

AU - Toni, Sonia

AU - Zioutas, Maximiliano

AU - Marigliano, Marco

AU - Cauvin, Vittoria

AU - Franceschi, Roberto

AU - Rabbone, Ivana

AU - Predieri, Barbara

AU - Schiaffini, Riccardo

AU - Salvatoni, Alessandro

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Aims: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes. Methods: A total of 261 children with both T1DM and CD were enrolled. Serum lipid profiles at CD diagnosis were compared with those after 1 year of GFD and with those of 224 matched children with T1DM alone. The adherence to GFD was judged by means of CD-related antibodies. Results: At CD diagnosis, children with T1DM + CD showed higher LDL cholesterol (LDL-C) compared to children with T1DM alone. Gluten withdrawal failed to normalize LDL-C levels, not even in completely adherent individuals. HbA1c values were not influenced by GFD. The youngest children were characterized at diagnosis by lower levels of total cholesterol and on treatment by a greater decrease in triglycerides levels. Conclusions: An unfavorable lipid profile, characterized not only by low HDL-C levels but also by high LDL-C values, may increase the risk of cardiovascular disease in children with T1DM and untreated CD. Therefore, a strict gluten-free diet is mandatory in these children, especially the youngest.

AB - Aims: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes. Methods: A total of 261 children with both T1DM and CD were enrolled. Serum lipid profiles at CD diagnosis were compared with those after 1 year of GFD and with those of 224 matched children with T1DM alone. The adherence to GFD was judged by means of CD-related antibodies. Results: At CD diagnosis, children with T1DM + CD showed higher LDL cholesterol (LDL-C) compared to children with T1DM alone. Gluten withdrawal failed to normalize LDL-C levels, not even in completely adherent individuals. HbA1c values were not influenced by GFD. The youngest children were characterized at diagnosis by lower levels of total cholesterol and on treatment by a greater decrease in triglycerides levels. Conclusions: An unfavorable lipid profile, characterized not only by low HDL-C levels but also by high LDL-C values, may increase the risk of cardiovascular disease in children with T1DM and untreated CD. Therefore, a strict gluten-free diet is mandatory in these children, especially the youngest.

KW - Celiac disease

KW - Childhood-onset T1DM

KW - Gluten-free diet

KW - HbA1c

KW - LDL cholesterol

KW - Triglycerides

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