Why does the brain (not) have glycogen?

Mauro Dinuzzo, Bruno Maraviglia, Federico Giove

Research output: Contribution to journalArticlepeer-review

Abstract

In the present paper we formulate the hypothesis that brain glycogen is a critical determinant in the modulation of carbohydrate supply at the cellular level. Specifically, we propose that mobilization of astrocytic glycogen after an increase in AMP levels during enhanced neuronal activity controls the concentration of glucose phosphates in astrocytes. This would result in modulation of glucose phosphorylation by hexokinase and upstream cell glucose uptake. This mechanism would favor glucose channeling to activated neurons, supplementing the already rich neuron-astrocyte metabolic and functional partnership with important implications for the energy compounds used to sustain neuronal activity. The hypothesis is based on recent modeling evidence suggesting that rapid glycogen breakdown can profoundly alter the short-term kinetics of glucose delivery to neurons and astrocytes. It is also based on review of the literature relevant to glycogen metabolism during physiological brain activity, with an emphasis on the metabolic pathways identifying both the origin and the fate of this glucose reserve.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalBioEssays
Volume33
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Astrocytes
  • Brain glycogen
  • Gluconeogenesis
  • Neuronal activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Why does the brain (not) have glycogen?'. Together they form a unique fingerprint.

Cite this