Why is community-associated MRSA spreading across the world and how will it change clinical practice?

Matteo Bassetti, Elena Nicco, Malgorzata Mikulska

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Meticillin-resistant Staphylococcus aureus (MRSA) emerged in 1960 and over the following 40 years was a problem confined largely to the healthcare setting. In the late 1990s the first US reports of so-called community-associated MRSA (CA-MRSA) infections appeared. CA-MRSA infections were defined as MRSA infections occurring in patients who had no identifiable predisposing risk factors, such as healthy children and young adults. CA-MRSA is associated with a novel genetic profile and phenotype; it is remarkably fit and capable of spreading within communities, it is virulent and is often susceptible to multiple narrow-spectrum antimicrobials other than β-lactams. CA-MRSA infections involve predominantly skin and soft tissue; however, necrotizing pneumonia and necrotizing fasciitis have been described. At present, several reports suggest that CA-MRSA may be replacing the hospital-acquired MRSA strains (HA-MRSA), with potentially catastrophic consequences. Given the rapid spread and the high virulence of CA-MRSA, global strategies are needed. Prompt, appropriate treatment, guided by the site and type of infection and risk factors for HA-MRSA or CA-MRSA, increases the chances of a successful outcome and is urgently needed.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
Volume34
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Methicillin
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Infection
Necrotizing Fasciitis
Lactams
Causality
Virulence
Young Adult
Delivery of Health Care
Phenotype
Skin

Keywords

  • Beta-lactam resistance
  • Community-acquired infection
  • Hospital infection
  • MRSA
  • Skin and soft tissue infections
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Why is community-associated MRSA spreading across the world and how will it change clinical practice? / Bassetti, Matteo; Nicco, Elena; Mikulska, Malgorzata.

In: International Journal of Antimicrobial Agents, Vol. 34, No. SUPPL. 1, 07.2009.

Research output: Contribution to journalArticle

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