The last decade witnessed important advances in the therapy of cardiovascular disease, mostly due to the prevention and treatment of thrombosis. Although thrombolytic and antiplatelet drugs have clearly reduced morbidity and mortality from myocardial infarction, a substantial percentage of events cannot be avoided by these treatments. Atherosclerosis and tissue ischemia are the pathogenetic situations that must now be dealt with to improve further our results. Leg ischemia is characterized by a progression of the disease from middle size arteries to arterioles and capillaries; from the muscular circulation to the microcirculation in the skin. When the stage of critical leg ischemia is reached we face the 'paradox' of tissue infarction in the absence of thrombosis. This clinically relevant condition is thus an ideal model to study complementary approaches to antithrombotic drugs. Current practices should be reevaluated and new promising drugs should be experimented against these in a controlled setting.
|Translated title of the contribution||Why study leg ischemia?|
|Number of pages||10|
|Journal||Ricerca e Pratica|
|Publication status||Published - 1993|
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