TY - JOUR
T1 - Wide-spectrum profile of inflammatory mediators in the plasma and scales of patients with psoriatic disease
AU - Deeva, Irina
AU - Mariani, Serena
AU - De Luca, Chiara
AU - Pacifico, Valeria
AU - Leoni, Luca
AU - Raskovic, Desanka
AU - Kharaeva, Zaira
AU - Korkina, Liudmila
AU - Pastore, Saveria
PY - 2010/2
Y1 - 2010/2
N2 - Psoriasis is a chronic recurrent inflammatory disorder of the skin. Clinical subtypes include psoriasis vulgaris (PV), psoriatic arthropathy, and erythrodermic psoriasis. Aim of this study was to analyse relevant inflammatory mediators in the plasma of patients with distinct subtypes of active psoriasis, and in the scales of mild-to-moderate PV patients, and correlation to disease severity. Compared to healthy controls (n = 10), patients affected by very severe forms of psoriasis (n = 30) were characterized by increased plasma levels of IL-4, IL-6, MCP-1, VEGF and in particular PDGFbb. Each group with severe psoriasis had distinct characteristic features of plasma cytokine profile. Mild-to-moderate PV patients (n = 35) showed higher levels of IL-4, IL-6, IL-10, and IL-13 when compared to healthy controls. No correlation was found between PV severity assessed by PASI (Psoriasis Area and Severity Index) and levels of these mediators. By contrast, disease severity correlated to scale levels of IP-10. For the first time, we found exaggerated circulating levels of the pro-angiogenic PDGFbb and VEGF in severe psoriasis. Evidence that the severity of skin symptoms correlated exclusively with scale levels of IP-10, but not with any up-regulated inflammatory mediator in plasma, suggests that distinct skin-independent processes contribute to the circulating cytokine profile in psoriasis.
AB - Psoriasis is a chronic recurrent inflammatory disorder of the skin. Clinical subtypes include psoriasis vulgaris (PV), psoriatic arthropathy, and erythrodermic psoriasis. Aim of this study was to analyse relevant inflammatory mediators in the plasma of patients with distinct subtypes of active psoriasis, and in the scales of mild-to-moderate PV patients, and correlation to disease severity. Compared to healthy controls (n = 10), patients affected by very severe forms of psoriasis (n = 30) were characterized by increased plasma levels of IL-4, IL-6, MCP-1, VEGF and in particular PDGFbb. Each group with severe psoriasis had distinct characteristic features of plasma cytokine profile. Mild-to-moderate PV patients (n = 35) showed higher levels of IL-4, IL-6, IL-10, and IL-13 when compared to healthy controls. No correlation was found between PV severity assessed by PASI (Psoriasis Area and Severity Index) and levels of these mediators. By contrast, disease severity correlated to scale levels of IP-10. For the first time, we found exaggerated circulating levels of the pro-angiogenic PDGFbb and VEGF in severe psoriasis. Evidence that the severity of skin symptoms correlated exclusively with scale levels of IP-10, but not with any up-regulated inflammatory mediator in plasma, suggests that distinct skin-independent processes contribute to the circulating cytokine profile in psoriasis.
KW - Chemokine
KW - Cytokine
KW - Growth factor
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=73649093378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73649093378&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2009.09.014
DO - 10.1016/j.cyto.2009.09.014
M3 - Article
C2 - 19879157
AN - SCOPUS:73649093378
VL - 49
SP - 163
EP - 170
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 2
ER -