TY - JOUR
T1 - Wine, beer and spirits and risk of oral and pharyngeal cancer
T2 - A case-control study from Italy and Switzerland
AU - Altieri, Andrea
AU - Bosetti, Cristina
AU - Gallus, Silvano
AU - Franceschi, Silvia
AU - Dal Maso, Luigino
AU - Talamini, Renato
AU - Levi, Fabio
AU - Negri, Eva
AU - Rodriguez, Teresa
AU - La Vecchia, Carlo
PY - 2004/10
Y1 - 2004/10
N2 - We examined the relation between consumption of different types of alcoholic beverages and the risk of oral and pharyngeal cancer, using data from a case-control study conducted in Italy and Switzerland between 1992 and 1997. This included a total of 749 cases of oral and pharyngeal cancer and 1,772 hospital controls, admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Significant trends in risk were found with increasing total alcohol intake, with multivariate odds ratios (OR) of 2.1 for drinkers of 3-4 drinks/day, as compared to abstainers or light drinkers (≤2 drinks/day), 5.0 for 5-7, 12.2 for 8-11 and 21.1 for ≥12 drinks/day. Similar increased risks for subsequent levels of consumption were found for wine drinkers. After allowance for wine intake, the ORs for beer drinkers were 1.2 for 1-2 drinks/day, and 2.3 for ≥3 drinks/day. Corresponding values for spirit drinkers were 1.0 and 1.9. Patterns of risk for wine drinkers were similar for wine only drinkers and drinkers of wine, plus beer and spirits. Our study indicates that in populations with frequent wine consumption, wine per se can strongly increase the risk of cancer of the oral cavity and pharynx, and confirms that the most prevalent alcoholic beverage in each population tends to be the one with the highest risk.
AB - We examined the relation between consumption of different types of alcoholic beverages and the risk of oral and pharyngeal cancer, using data from a case-control study conducted in Italy and Switzerland between 1992 and 1997. This included a total of 749 cases of oral and pharyngeal cancer and 1,772 hospital controls, admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Significant trends in risk were found with increasing total alcohol intake, with multivariate odds ratios (OR) of 2.1 for drinkers of 3-4 drinks/day, as compared to abstainers or light drinkers (≤2 drinks/day), 5.0 for 5-7, 12.2 for 8-11 and 21.1 for ≥12 drinks/day. Similar increased risks for subsequent levels of consumption were found for wine drinkers. After allowance for wine intake, the ORs for beer drinkers were 1.2 for 1-2 drinks/day, and 2.3 for ≥3 drinks/day. Corresponding values for spirit drinkers were 1.0 and 1.9. Patterns of risk for wine drinkers were similar for wine only drinkers and drinkers of wine, plus beer and spirits. Our study indicates that in populations with frequent wine consumption, wine per se can strongly increase the risk of cancer of the oral cavity and pharynx, and confirms that the most prevalent alcoholic beverage in each population tends to be the one with the highest risk.
KW - Alcohol drinking
KW - Case-control study
KW - Mouth neoplasms
KW - Pharyngeal neoplasms
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=5644289618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5644289618&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2004.04.005
DO - 10.1016/j.oraloncology.2004.04.005
M3 - Article
C2 - 15380168
AN - SCOPUS:5644289618
VL - 40
SP - 904
EP - 909
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 9
ER -