TY - JOUR
T1 - Wine consumption and risk of cardiovascular events after myocardial infarction
T2 - Results from the GISSI-Prevenzione trial
AU - Levantesi, Giacomo
AU - Marfisi, Rosamaria
AU - Mozaffarian, Dariush
AU - Franzosi, Maria Grazia
AU - Maggioni, Aldopietro
AU - Nicolosi, Gian Luigi
AU - Schweiger, Carlo
AU - Silletta, Mariagiuseppina
AU - Tavazzi, Luigi
AU - Tognoni, Gianni
AU - Marchioli, Roberto
PY - 2013/3/10
Y1 - 2013/3/10
N2 - Background: To evaluate the association of wine intake with incident cardiovascular events (CVE) and total mortality after myocardial infarction (MI). Methods: We used prospectively ascertained information among 11,248 Italian patients with recent MI enrolled in the GISSI-Prevenzione Trial. Usual wine consumption has been categorised as never/almost never, up to 0.5 L/day, and > 0.5 L/day. Multiple imputation was used for missing values at baseline and during follow-up. We assessed adjudicated cumulative incidence of major CVE during 3.5 years of follow-up and total mortality at long-term follow-up (7.3 years), respectively. Multivariate Cox proportional hazards models were fitted to estimate hazard ratios (HR) first using data at baseline and then updated using time-varying covariates. Results: During 37,021 person-years of follow-up, 1168 CVE occurred. Moderate wine intake at baseline was associated with significantly reduced risk of CVE (adjusted HR 0.87; 95% CI 0.76-0.99) as compared with non-drinkers. In time-updated analyses, results were virtually the same, though they were barely statistically not significant (adjusted HR 0.88; 95% CI 0.77-1.00). Wine intake was associated with lower risk of total mortality. In time-updated adjusted analyses, patients with wine consumption up to 0.5 L/day (HR 0.83; 95% CI 0.74-0.92) and > 0.5 L/day (HR 0.77; 95% CI 0.63-0.94) had lower mortality compared with non-drinkers (P for trend = 0.0003). Conclusions: Among patients with established heart disease, moderate consumption of wine seems to be associated with lower incidence of CVE and total mortality as compared with non drinkers.
AB - Background: To evaluate the association of wine intake with incident cardiovascular events (CVE) and total mortality after myocardial infarction (MI). Methods: We used prospectively ascertained information among 11,248 Italian patients with recent MI enrolled in the GISSI-Prevenzione Trial. Usual wine consumption has been categorised as never/almost never, up to 0.5 L/day, and > 0.5 L/day. Multiple imputation was used for missing values at baseline and during follow-up. We assessed adjudicated cumulative incidence of major CVE during 3.5 years of follow-up and total mortality at long-term follow-up (7.3 years), respectively. Multivariate Cox proportional hazards models were fitted to estimate hazard ratios (HR) first using data at baseline and then updated using time-varying covariates. Results: During 37,021 person-years of follow-up, 1168 CVE occurred. Moderate wine intake at baseline was associated with significantly reduced risk of CVE (adjusted HR 0.87; 95% CI 0.76-0.99) as compared with non-drinkers. In time-updated analyses, results were virtually the same, though they were barely statistically not significant (adjusted HR 0.88; 95% CI 0.77-1.00). Wine intake was associated with lower risk of total mortality. In time-updated adjusted analyses, patients with wine consumption up to 0.5 L/day (HR 0.83; 95% CI 0.74-0.92) and > 0.5 L/day (HR 0.77; 95% CI 0.63-0.94) had lower mortality compared with non-drinkers (P for trend = 0.0003). Conclusions: Among patients with established heart disease, moderate consumption of wine seems to be associated with lower incidence of CVE and total mortality as compared with non drinkers.
KW - Alcohol
KW - Cardiovascular diseases
KW - Mortality
KW - Prevention
KW - Risk factors
KW - Wine
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U2 - 10.1016/j.ijcard.2011.06.053
DO - 10.1016/j.ijcard.2011.06.053
M3 - Article
C2 - 21737162
AN - SCOPUS:84874548731
VL - 163
SP - 282
EP - 287
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -